ID   CALC_LITCT              Reviewed;          32 AA.
AC   P0C234;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-NOV-2006, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Calcitonin;
OS   Lithobates catesbeianus (American bullfrog) (Rana catesbeiana).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX   NCBI_TaxID=8400;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT PRO-32, AND FUNCTION.
RX   PubMed=9245522; DOI=10.1006/gcen.1997.6905;
RA   Yoshida A., Kaiya H., Takei Y., Watanabe T.X., Nakajima K., Suzuki N.,
RA   Sasayama Y.;
RT   "Primary structure and bioactivity of bullfrog calcitonin.";
RL   Gen. Comp. Endocrinol. 107:147-152(1997).
CC   -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC       and phosphate in blood by promoting the incorporation of those ions in
CC       the bones. {ECO:0000269|PubMed:9245522}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   AlphaFoldDB; P0C234; -.
DR   SMR; P0C234; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021118; Calcitonin.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PRINTS; PR00270; CALCITONINA.
DR   SMART; SM00113; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   CHAIN           1..32
FT                   /note="Calcitonin"
FT                   /id="PRO_0000260292"
FT   MOD_RES         32
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:9245522"
FT   DISULFID        1..7
SQ   SEQUENCE   32 AA;  3426 MW;  E3B9893F3BA6A70B CRC64;
     CSGLSTCALM KLSQDLHRFN SYPRTNVGAG TP