CALC_MOUSE
ID CALC_MOUSE Reviewed; 136 AA.
AC P70160; Q8K1K5;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Calcitonin;
DE Flags: Precursor;
GN Name=Calca; Synonyms=Calc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thyroid;
RX PubMed=8806650; DOI=10.1006/bbrc.1996.1371;
RA Rehli M., Luger K., Beier W., Falk W.;
RT "Molecular cloning and expression of mouse procalcitonin.";
RL Biochem. Biophys. Res. Commun. 226:420-425(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=11761712; DOI=10.3109/10425170109047567;
RA Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.;
RT "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha
RT and beta genes.";
RL DNA Seq. 12:131-135(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC and phosphate in blood by promoting the incorporation of those ions in
CC the bones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Calcitonin;
CC IsoId=P70160-1; Sequence=Displayed;
CC Name=Calcitonin-gene related peptide I;
CC IsoId=Q99JA0-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR EMBL; X97991; CAA66630.1; -; mRNA.
DR EMBL; AF325522; AAK18180.1; -; Genomic_DNA.
DR EMBL; AF325521; AAK18180.1; JOINED; Genomic_DNA.
DR EMBL; BC030071; AAH30071.1; -; mRNA.
DR CCDS; CCDS21763.1; -. [P70160-1]
DR PIR; JC4977; JC4977.
DR RefSeq; NP_001292545.1; NM_001305616.1. [P70160-1]
DR RefSeq; NP_031613.2; NM_007587.2. [P70160-1]
DR RefSeq; XP_017177447.1; XM_017321958.1.
DR RefSeq; XP_017177448.1; XM_017321959.1.
DR RefSeq; XP_017177449.1; XM_017321960.1.
DR AlphaFoldDB; P70160; -.
DR SMR; P70160; -.
DR STRING; 10090.ENSMUSP00000032907; -.
DR GlyGen; P70160; 1 site.
DR PhosphoSitePlus; P70160; -.
DR PaxDb; P70160; -.
DR PRIDE; P70160; -.
DR ProteomicsDB; 265326; -. [P70160-1]
DR Antibodypedia; 3493; 1836 antibodies from 46 providers.
DR DNASU; 12310; -.
DR Ensembl; ENSMUST00000032907; ENSMUSP00000032907; ENSMUSG00000030669. [P70160-1]
DR Ensembl; ENSMUST00000206853; ENSMUSP00000146328; ENSMUSG00000030669. [P70160-1]
DR GeneID; 12310; -.
DR UCSC; uc009jig.2; mouse. [P70160-1]
DR CTD; 796; -.
DR MGI; MGI:2151253; Calca.
DR VEuPathDB; HostDB:ENSMUSG00000030669; -.
DR eggNOG; ENOG502RZI5; Eukaryota.
DR GeneTree; ENSGT00940000162876; -.
DR HOGENOM; CLU_122444_0_0_1; -.
DR InParanoid; P70160; -.
DR OrthoDB; 1454612at2759; -.
DR PhylomeDB; P70160; -.
DR TreeFam; TF333069; -.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-419812; Calcitonin-like ligand receptors.
DR BioGRID-ORCS; 12310; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Calca; mouse.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; P70160; protein.
DR Bgee; ENSMUSG00000030669; Expressed in facial nucleus and 98 other tissues.
DR ExpressionAtlas; P70160; baseline and differential.
DR Genevisible; P70160; MM.
DR GO; GO:0030424; C:axon; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; IDA:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0043195; C:terminal bouton; IDA:MGI.
DR GO; GO:0031716; F:calcitonin receptor binding; IDA:MGI.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; IDA:MGI.
DR GO; GO:0032147; P:activation of protein kinase activity; ISO:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:MGI.
DR GO; GO:0007568; P:aging; IEA:Ensembl.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:MGI.
DR GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:MGI.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IGI:MGI.
DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI.
DR GO; GO:0007566; P:embryo implantation; ISO:MGI.
DR GO; GO:0043542; P:endothelial cell migration; ISO:MGI.
DR GO; GO:0001935; P:endothelial cell proliferation; ISO:MGI.
DR GO; GO:0007631; P:feeding behavior; IDA:MGI.
DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:MGI.
DR GO; GO:0006954; P:inflammatory response; IDA:MGI.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:MGI.
DR GO; GO:0002548; P:monocyte chemotaxis; ISO:MGI.
DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI.
DR GO; GO:0045779; P:negative regulation of bone resorption; ISO:MGI.
DR GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; ISO:MGI.
DR GO; GO:0030279; P:negative regulation of ossification; IMP:MGI.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:MGI.
DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0001976; P:nervous system process involved in regulation of systemic arterial blood pressure; ISA:MGI.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI.
DR GO; GO:0001503; P:ossification; IMP:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISO:MGI.
DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; ISO:MGI.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:MGI.
DR GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
DR GO; GO:0031623; P:receptor internalization; ISO:MGI.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0008016; P:regulation of heart contraction; ISO:MGI.
DR GO; GO:0009408; P:response to heat; IMP:MGI.
DR GO; GO:0048265; P:response to pain; IMP:MGI.
DR GO; GO:0006939; P:smooth muscle contraction; IDA:MGI.
DR GO; GO:0048240; P:sperm capacitation; ISA:MGI.
DR GO; GO:0001944; P:vasculature development; ISO:MGI.
DR GO; GO:0042311; P:vasodilation; ISO:MGI.
DR InterPro; IPR021118; Calcitonin.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505; PTHR10505; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00270; CALCITONINA.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Disulfide bond; Glycoprotein; Hormone; Phosphoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT PROPEP 26..82
FT /id="PRO_0000004056"
FT PEPTIDE 85..116
FT /note="Calcitonin"
FT /id="PRO_0000004057"
FT PROPEP 121..136
FT /id="PRO_0000004058"
FT REGION 63..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P01257"
FT MOD_RES 116
FT /note="Proline amide"
FT /evidence="ECO:0000250"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 85..91
FT /evidence="ECO:0000250"
FT CONFLICT 108
FT /note="Q -> K (in Ref. 3; AAH30071)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 136 AA; 15141 MW; B7F1DD27F7E10DE5 CRC64;
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK
ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL NKFHTFPQTS IGVEAPGKKR
DVAKDLETNH QSHFGN
