ID   CALC_PIG                Reviewed;          32 AA.
AC   P01259;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Calcitonin;
GN   Name=CALCA; Synonyms=CALC;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT PRO-32.
RX   PubMed=5240032; DOI=10.1073/pnas.59.4.1321;
RA   Potts J.T. Jr., Niall H.D., Keutmann H.T., Brewer H.B. Jr., Deftos L.J.;
RT   "The amino acid sequence of porcine thyrocalcitonin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 59:1321-1328(1968).
RN   [2]
RP   PROTEIN SEQUENCE.
RX   PubMed=5462122; DOI=10.1021/bi00810a004;
RA   Barg W.F. Jr., Englert M.E., Davies M.C., Colucci D.F., Snedeker E.H.,
RA   Dziobkowski C., Bell P.H.;
RT   "Degradation and structure of porcine calcitonin-1.";
RL   Biochemistry 9:1671-1676(1970).
RN   [3]
RP   PROTEIN SEQUENCE.
RX   PubMed=5693288; DOI=10.1002/hlca.660510430;
RA   Neher R., Riniker B., Zuber H., Rittel W., Kahnt F.W.;
RT   "Thyrocalcitonin. II. Structure of alpha-thyrocalcitonin.";
RL   Helv. Chim. Acta 51:917-924(1968).
CC   -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC       and phosphate in blood by promoting the incorporation of those ions in
CC       the bones.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR   PIR; A93769; TCPG.
DR   AlphaFoldDB; P01259; -.
DR   SMR; P01259; -.
DR   STRING; 9823.ENSSSCP00000022117; -.
DR   MetOSite; P01259; -.
DR   PaxDb; P01259; -.
DR   PRIDE; P01259; -.
DR   eggNOG; ENOG502RZI5; Eukaryota.
DR   HOGENOM; CLU_122444_0_0_1; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR021118; Calcitonin.
DR   InterPro; IPR018360; Calcitonin_CS.
DR   InterPro; IPR001693; Calcitonin_peptide-like.
DR   PRINTS; PR00270; CALCITONINA.
DR   SMART; SM00113; CALCITONIN; 1.
DR   PROSITE; PS00258; CALCITONIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Reference proteome; Secreted.
FT   PEPTIDE         1..32
FT                   /note="Calcitonin"
FT                   /id="PRO_0000044666"
FT   MOD_RES         32
FT                   /note="Proline amide"
FT                   /evidence="ECO:0000269|PubMed:5240032"
FT   DISULFID        1..7
FT                   /evidence="ECO:0000269|PubMed:5240032"
SQ   SEQUENCE   32 AA;  3607 MW;  EDE755ED2FE6EA09 CRC64;
     CSNLSTCVLS AYWRNLNNFH RFSGMGFGPE TP