CALC_RAT
ID CALC_RAT Reviewed; 136 AA.
AC P01257;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Calcitonin;
DE Flags: Precursor;
GN Name=Calca; Synonyms=Calc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND AMIDATION AT PRO-116.
RX PubMed=6264603; DOI=10.1126/science.6264603;
RA Jacobs J.W., Goodman R.H., Chin W.W., Dee P.C., Habener J.F., Bell N.H.,
RA Potts J.T. Jr.;
RT "Calcitonin messenger RNA encodes multiple polypeptides in a single
RT precursor.";
RL Science 213:457-459(1981).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=6400492;
RA Rosenfeld M.G., Amara S.G., Evans R.M.;
RT "Alternative RNA processing events as a critical developmental regulatory
RT strategy in neuroendocrine gene expression.";
RL Biochem. Soc. Symp. 49:27-44(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 83-136.
RX PubMed=6933496; DOI=10.1073/pnas.77.8.4444;
RA Amara S.G., David D.N., Rosenfeld M.G., Roos B.A., Evans R.M.;
RT "Characterization of rat calcitonin mRNA.";
RL Proc. Natl. Acad. Sci. U.S.A. 77:4444-4448(1980).
RN [4]
RP PROTEIN SEQUENCE OF 85-116.
RX PubMed=1278175; DOI=10.1111/j.1432-1033.1976.tb10340.x;
RA Raulais D., Hagaman J., Ontjes D.A., Lundblad R.L., Kingdon H.S.;
RT "The complete amino-acid sequence of rat thyrocalcitonin.";
RL Eur. J. Biochem. 64:607-611(1976).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium
CC and phosphate in blood by promoting the incorporation of those ions in
CC the bones.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Calcitonin;
CC IsoId=P01257-1; Sequence=Displayed;
CC Name=Calcitonin-gene related peptide I;
CC IsoId=P01256-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}.
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DR EMBL; V01230; CAA24540.1; -; mRNA.
DR EMBL; V01228; CAA24538.1; -; mRNA.
DR EMBL; V01229; CAA24539.1; -; mRNA.
DR EMBL; M26137; AAA40849.1; -; mRNA.
DR EMBL; M31027; AAB59681.1; -; Genomic_DNA.
DR EMBL; L00109; AAB59681.1; JOINED; Genomic_DNA.
DR EMBL; L00110; AAB59681.1; JOINED; Genomic_DNA.
DR PIR; A94259; TCRT.
DR RefSeq; NP_059034.1; NM_017338.2. [P01257-1]
DR RefSeq; XP_008757898.1; XM_008759676.2. [P01257-1]
DR AlphaFoldDB; P01257; -.
DR SMR; P01257; -.
DR BioGRID; 246427; 3.
DR STRING; 10116.ENSRNOP00000014948; -.
DR GlyGen; P01257; 1 site.
DR iPTMnet; P01257; -.
DR PhosphoSitePlus; P01257; -.
DR PaxDb; P01257; -.
DR Ensembl; ENSRNOT00000014948; ENSRNOP00000014948; ENSRNOG00000011130. [P01257-1]
DR GeneID; 24241; -.
DR CTD; 796; -.
DR RGD; 2254; Calca.
DR eggNOG; ENOG502RZI5; Eukaryota.
DR GeneTree; ENSGT00940000162876; -.
DR HOGENOM; CLU_122444_0_0_1; -.
DR InParanoid; P01257; -.
DR OrthoDB; 1454612at2759; -.
DR PhylomeDB; P01257; -.
DR TreeFam; TF333069; -.
DR Reactome; R-RNO-419812; Calcitonin-like ligand receptors.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000011130; Expressed in stomach and 8 other tissues.
DR ExpressionAtlas; P01257; baseline and differential.
DR Genevisible; P01257; RN.
DR GO; GO:0030424; C:axon; IDA:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005576; C:extracellular region; ISO:RGD.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0043195; C:terminal bouton; ISO:RGD.
DR GO; GO:0031716; F:calcitonin receptor binding; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0005184; F:neuropeptide hormone activity; TAS:RGD.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0007190; P:activation of adenylate cyclase activity; ISO:RGD.
DR GO; GO:0032147; P:activation of protein kinase activity; ISO:RGD.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0007568; P:aging; IEP:RGD.
DR GO; GO:0097647; P:amylin receptor signaling pathway; ISO:RGD.
DR GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; ISO:RGD.
DR GO; GO:1990408; P:calcitonin gene-related peptide receptor signaling pathway; ISO:RGD.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IEP:RGD.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.
DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; ISO:RGD.
DR GO; GO:0007566; P:embryo implantation; ISO:RGD.
DR GO; GO:0043542; P:endothelial cell migration; ISO:RGD.
DR GO; GO:0001935; P:endothelial cell proliferation; ISO:RGD.
DR GO; GO:0007631; P:feeding behavior; ISO:RGD.
DR GO; GO:0002031; P:G protein-coupled receptor internalization; ISO:RGD.
DR GO; GO:0006954; P:inflammatory response; IEP:RGD.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:RGD.
DR GO; GO:0002548; P:monocyte chemotaxis; ISO:RGD.
DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:RGD.
DR GO; GO:0045779; P:negative regulation of bone resorption; ISO:RGD.
DR GO; GO:0010523; P:negative regulation of calcium ion transport into cytosol; ISO:RGD.
DR GO; GO:0030279; P:negative regulation of ossification; ISO:RGD.
DR GO; GO:0045671; P:negative regulation of osteoclast differentiation; ISO:RGD.
DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IMP:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISO:RGD.
DR GO; GO:0001503; P:ossification; IEA:Ensembl.
DR GO; GO:0045785; P:positive regulation of cell adhesion; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR GO; GO:0051482; P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; ISO:RGD.
DR GO; GO:0032730; P:positive regulation of interleukin-1 alpha production; ISO:RGD.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD.
DR GO; GO:0045651; P:positive regulation of macrophage differentiation; ISO:RGD.
DR GO; GO:0006468; P:protein phosphorylation; ISO:RGD.
DR GO; GO:0031623; P:receptor internalization; ISO:RGD.
DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; ISO:RGD.
DR GO; GO:0008016; P:regulation of heart contraction; IDA:RGD.
DR GO; GO:0009408; P:response to heat; ISO:RGD.
DR GO; GO:0048265; P:response to pain; ISO:RGD.
DR GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0001944; P:vasculature development; ISO:RGD.
DR GO; GO:0042311; P:vasodilation; IDA:RGD.
DR InterPro; IPR021118; Calcitonin.
DR InterPro; IPR021117; Calcitonin-like.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR018360; Calcitonin_CS.
DR InterPro; IPR001693; Calcitonin_peptide-like.
DR PANTHER; PTHR10505; PTHR10505; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00270; CALCITONINA.
DR SMART; SM00113; CALCITONIN; 1.
DR PROSITE; PS00258; CALCITONIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Amidation; Cleavage on pair of basic residues;
KW Direct protein sequencing; Disulfide bond; Glycoprotein; Hormone;
KW Phosphoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT PROPEP 26..82
FT /id="PRO_0000004062"
FT PEPTIDE 85..116
FT /note="Calcitonin"
FT /id="PRO_0000004063"
FT PROPEP 121..136
FT /id="PRO_0000004064"
FT REGION 64..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 42
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 116
FT /note="Proline amide"
FT /evidence="ECO:0000269|PubMed:6264603"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000305"
FT DISULFID 85..91
FT /evidence="ECO:0000269|PubMed:1278175"
SQ SEQUENCE 136 AA; 15103 MW; A197358A802222F7 CRC64;
MGFLKFSPFL VVSILLLYQA CGLQAVPLRS TLESSPGMAT LSEEEARLLA ALVQNYMQMK
VRELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL NKFHTFPQTS IGVGAPGKKR
DMAKDLETNH HPYFGN
