ID   VLF1_NPVOP              Reviewed;         374 AA.
AC   O10330;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Very late expression factor 1;
GN   Name=VLF-1; ORFNames=ORF80;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Involved in very late gene activation. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01246}.
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DR   EMBL; U75930; AAC59079.1; -; Genomic_DNA.
DR   RefSeq; NP_046236.1; NC_001875.2.
DR   SMR; O10330; -.
DR   GeneID; 912008; -.
DR   KEGG; vg:912008; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; Transcription; Transcription regulation.
FT   CHAIN           1..374
FT                   /note="Very late expression factor 1"
FT                   /id="PRO_0000132876"
FT   DOMAIN          169..349
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   REGION          328..374
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        351..374
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        210
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        239
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        303
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        326
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        335
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   374 AA;  43165 MW;  593F8FC0B20C5B29 CRC64;
     MDGLGVRNET TFNDWKARIQ SASRFEHVFD LATDRQRCTP DEVKNDSLWS KYMFPKPFAP
     TTLKSYKSRL IKIIFSLVEE ADLQNPAYDL DREFDSVEFQ HLLVSPKELC KRMLELRSVT
     KETLQLTINF YTNAMNLPEF KIPRMVMLPR DKELKTIREK EKNFMLKNAI DTILNFIDSK
     IKLMNSDYVH DRGLIRGAIV FCIMLGTGMR INEARQLSVD DLNVLIKKGK LRSDTIGLKR
     KRSRKNTLNN IKTKPLELAR EIYARNPTVL QISKNTSTPF KDFRRLLDEA GVEMERPRSN
     MIRHYLSSNL YNSGVPLQKV ARLMNHESPA STKPYLNKYN FDESSSDEES GGNNRDSSTG
     SSANSSSLYY QTGD