ID   VLLY_VIBVU              Reviewed;         357 AA.
AC   O06695;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2003, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Hemolysin VllY;
GN   Name=vllY; OrderedLocusNames=VV1_2768;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CKM-1;
RA   Chang M.C.;
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the 4HPPD family. {ECO:0000305}.
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DR   EMBL; U97357; AAC45755.1; -; Genomic_DNA.
DR   EMBL; AE016795; AAO11111.1; -; Genomic_DNA.
DR   RefSeq; WP_011080604.1; NC_004459.3.
DR   AlphaFoldDB; O06695; -.
DR   SMR; O06695; -.
DR   PRIDE; O06695; -.
DR   EnsemblBacteria; AAO11111; AAO11111; VV1_2768.
DR   KEGG; vvu:VV1_2768; -.
DR   HOGENOM; CLU_034004_1_0_6; -.
DR   OMA; DPFPVKG; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0009072; P:aromatic amino acid family metabolic process; IEA:InterPro.
DR   GO; GO:0019836; P:hemolysis by symbiont of host erythrocytes; IDA:UniProtKB.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   CDD; cd07250; HPPD_C_like; 1.
DR   CDD; cd08342; HPPD_N_like; 1.
DR   Gene3D; 3.10.180.10; -; 2.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR041735; 4OHPhenylPyrv_dOase_C.
DR   InterPro; IPR041736; 4OHPhenylPyrv_dOase_N.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR11959; PTHR11959; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   SUPFAM; SSF54593; SSF54593; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   3: Inferred from homology;
KW   Cytolysis; Hemolysis; Iron; Metal-binding; Repeat; Toxin; Virulence.
FT   CHAIN           1..357
FT                   /note="Hemolysin VllY"
FT                   /id="PRO_0000088414"
FT   DOMAIN          12..132
FT                   /note="VOC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   DOMAIN          162..313
FT                   /note="VOC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01163"
FT   BINDING         165
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         243
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   BINDING         322
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        169..170
FT                   /note="NV -> TL (in Ref. 1; AAC45755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173
FT                   /note="G -> R (in Ref. 1; AAC45755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        181..190
FT                   /note="FYERIGNFRE -> SMSVLVISVK (in Ref. 1; AAC45755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="G -> R (in Ref. 1; AAC45755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        209
FT                   /note="T -> N (in Ref. 1; AAC45755)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        286
FT                   /note="D -> N (in Ref. 1; AAC45755)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   357 AA;  40280 MW;  BF3CA13EF2936777 CRC64;
     MVDAINPLGT DGFEFVEYTA ADNTGIEQLK HLFSSLGFAE VAKHRSKEAW LYRQGDINFV
     VNAQPHSQAE EFAKVHGPSV CGMAFRVQDA ASALKHALTN GAEEYKTEIG PMELSIPAVY
     GIGGSLLYFV DRYGKQSIYD VDFRFYDDAA QRLAKSDVGL YEIDHLTHNV KRGNMDTWAG
     FYERIGNFRE IRYFDIEGKL TGLVSRAMTA PCGKIRIPIN ESSDDKSQIE EFIREYNGEG
     IQHIALTTDD IYQTVQTLRD RGMDFMPTPD TYYDKVDSRV EGHKEDVSRL RDLRILIDGA
     PLKDGILLQI FTQTVIGPVF FEIIQRKGNE GFGEGNFKAL FESIEEDQIR RGVLNNA