VLN4_ORYSI
ID VLN4_ORYSI Reviewed; 946 AA.
AC B8ATT7; Q01KK5;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Villin-4 {ECO:0000250|UniProtKB:Q0JAD9};
GN Name=VLN4 {ECO:0000250|UniProtKB:Q0JAD9};
GN ORFNames=OsI_17280 {ECO:0000312|EMBL:EEC77939.1},
GN OSIGBa0118P15.6 {ECO:0000312|EMBL:CAH66716.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Guang-Lu-Ai No.4;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: Ca(2+)-regulated actin-binding protein (By similarity). Binds
CC actin microfilaments (MFs). Involved in actin filament bundling,
CC severing and capping. Caps the barbed end of actin filaments and is
CC able to sever them in a calcium-dependent manner (By similarity).
CC {ECO:0000250|UniProtKB:O81644, ECO:0000250|UniProtKB:Q10L71}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:O81644}.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family. {ECO:0000305}.
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DR EMBL; CR855138; CAH66716.1; -; Genomic_DNA.
DR EMBL; CM000129; EEC77939.1; -; Genomic_DNA.
DR AlphaFoldDB; B8ATT7; -.
DR SMR; B8ATT7; -.
DR STRING; 39946.B8ATT7; -.
DR EnsemblPlants; BGIOSGA014405-TA; BGIOSGA014405-PA; BGIOSGA014405.
DR Gramene; BGIOSGA014405-TA; BGIOSGA014405-PA; BGIOSGA014405.
DR HOGENOM; CLU_002568_2_1_1; -.
DR OMA; HIWITEN; -.
DR Proteomes; UP000007015; Chromosome 4.
DR GO; GO:0032432; C:actin filament bundle; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0051693; P:actin filament capping; ISS:UniProtKB.
DR GO; GO:0007015; P:actin filament organization; ISS:UniProtKB.
DR GO; GO:0051014; P:actin filament severing; ISS:UniProtKB.
DR Gene3D; 1.10.950.10; -; 1.
DR Gene3D; 3.40.20.10; -; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977; PTHR11977; 1.
DR Pfam; PF00626; Gelsolin; 4.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF47050; SSF47050; 1.
DR SUPFAM; SSF82754; SSF82754; 2.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping; Actin-binding; Calcium; Cytoplasm; Cytoskeleton;
KW Reference proteome; Repeat.
FT CHAIN 1..946
FT /note="Villin-4"
FT /id="PRO_0000438166"
FT REPEAT 28..109
FT /note="Gelsolin-like 1"
FT /evidence="ECO:0000255"
FT REPEAT 152..219
FT /note="Gelsolin-like 2"
FT /evidence="ECO:0000255"
FT REPEAT 274..339
FT /note="Gelsolin-like 3"
FT /evidence="ECO:0000255"
FT REPEAT 641..715
FT /note="Gelsolin-like 4"
FT /evidence="ECO:0000255"
FT DOMAIN 881..946
FT /note="HP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00595"
FT REGION 744..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 846..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 635..637
FT /note="ENL -> GNQ (in Ref. 1; CAH66716)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 946 AA; 105655 MW; D95D052FA5B9FC9F CRC64;
MSISMKDVDP AFRGVGQKDG LEVWRIENFK PVPVPTSSHG KFYMGDSYII LKTTALKNGS
FRHDLHYWLG KDTSQDEAGT AAILTVELDA ALGGRAVQYR EVQGGETEKL LSYFRPCIMP
QPGGVASGFN HVEVNQQDHV TRLYVCQGKH VVHVKEVPFV RSSLNHEDIF ILDTANKIFQ
FNGSNSCIQE RAKALEVVQY IKDTFHEGKC EVAAVEDGKL MADTEAGEFW GLFGGFAPLP
KKTSSEDNGD DKETVTKLLC FNQGTLEHIS FESLEHELLE TNKCYLLDCG AEMYVWMGRG
TSLQVRKGAS EAAEKLLIDE NRKGSNVIKV IEGFETIMFK SKFNKWPPTP DLKLSSEDGR
GKVAALLRSQ GLDVKGLMKA APEEEEPQPY IDCTGHLQVW RVNGDGKTLL SSSDQSKLYT
GDCYIFQYTY TGDDKEECLI GTWFGKKSVE EDRTSAISLA SKMFQAAKFQ AAQARLYEGK
EPIQFFVIFQ SLQVFKGGLS SGYKNFIAVN GTDDDTYVEG GLALFRIQGS GSENMQAIQV
DAVSSSLNSS YCYILHNGNT VFTWTGNLTT SLDNDLVERQ LDVIKPDLPS RSQKEGRETD
QFWELLGGKC KYSNKKIGKE NESDPHLFSC ILSKENLKVK EIHHFTQDDL MAEDIFVLDC
RTDLFVWVGQ EVDAKLRSQA MDIGEKFLLH DFLMENLSQD TPIFIVTEGS EPQFFTRFFT
WDSAKSLMHG SSYQRKLAIV KGGATPSLDK PKRRTPAFSG RNAGQDKSQQ RTRSMSHSPE
RHRIRGRSPA FTAIASAFEN PSTRYLSTPP PAVKKLFPRS GGSELPKTSS KQSAINALTS
AFEGPTKSTI PKSVKVSPEA EKAIQEEGST IGESENEPED DENSTIYPYE RLTTTSDDPA
PDIDVTKREV YLSSVEFAEK FGMTRASFKN LPKWKQNRLK SDLQLF
