VLN5_ORYSJ
ID VLN5_ORYSJ Reviewed; 955 AA.
AC Q0J716;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Villin-5 {ECO:0000303|PubMed:20807878};
GN Name=VLN5 {ECO:0000303|PubMed:20807878};
GN OrderedLocusNames=LOC_Os08g14230 {ECO:0000305},
GN Os08g0240800 {ECO:0000312|EMBL:BAF23249.1};
GN ORFNames=OSNPB_080240800 {ECO:0000312|EMBL:BAT04494.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=20807878; DOI=10.1105/tpc.110.076240;
RA Khurana P., Henty J.L., Huang S., Staiger A.M., Blanchoin L., Staiger C.J.;
RT "Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities
RT in actin bundle formation and turnover.";
RL Plant Cell 22:2727-2748(2010).
CC -!- FUNCTION: Ca(2+)-regulated actin-binding protein (By similarity). Binds
CC actin microfilaments (MFs). Involved in actin filament bundling,
CC severing and capping. Caps the barbed end of actin filaments and is
CC able to sever them in a calcium-dependent manner (By similarity).
CC {ECO:0000250|UniProtKB:O81644, ECO:0000250|UniProtKB:Q10L71}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000250|UniProtKB:O81644}.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family. {ECO:0000305}.
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DR EMBL; AP008214; BAF23249.1; -; Genomic_DNA.
DR EMBL; AP014964; BAT04494.1; -; Genomic_DNA.
DR RefSeq; XP_015650776.1; XM_015795290.1.
DR AlphaFoldDB; Q0J716; -.
DR SMR; Q0J716; -.
DR STRING; 4530.OS08T0240800-01; -.
DR PaxDb; Q0J716; -.
DR PRIDE; Q0J716; -.
DR EnsemblPlants; Os08t0240800-01; Os08t0240800-01; Os08g0240800.
DR GeneID; 4345036; -.
DR Gramene; Os08t0240800-01; Os08t0240800-01; Os08g0240800.
DR KEGG; osa:4345036; -.
DR eggNOG; KOG0443; Eukaryota.
DR HOGENOM; CLU_002568_2_1_1; -.
DR InParanoid; Q0J716; -.
DR OMA; DNRTKTH; -.
DR OrthoDB; 1376537at2759; -.
DR Proteomes; UP000000763; Chromosome 8.
DR Proteomes; UP000059680; Chromosome 8.
DR GO; GO:0032432; C:actin filament bundle; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; ISS:UniProtKB.
DR GO; GO:0051693; P:actin filament capping; ISS:UniProtKB.
DR GO; GO:0007015; P:actin filament organization; ISS:UniProtKB.
DR GO; GO:0051014; P:actin filament severing; ISS:UniProtKB.
DR Gene3D; 1.10.950.10; -; 1.
DR Gene3D; 3.40.20.10; -; 6.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977; PTHR11977; 1.
DR Pfam; PF00626; Gelsolin; 4.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF47050; SSF47050; 1.
DR SUPFAM; SSF82754; SSF82754; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping; Actin-binding; Calcium; Cytoplasm; Cytoskeleton;
KW Reference proteome; Repeat.
FT CHAIN 1..955
FT /note="Villin-5"
FT /id="PRO_0000438168"
FT REPEAT 29..111
FT /note="Gelsolin-like 1"
FT /evidence="ECO:0000255"
FT REPEAT 152..218
FT /note="Gelsolin-like 2"
FT /evidence="ECO:0000255"
FT REPEAT 274..339
FT /note="Gelsolin-like 3"
FT /evidence="ECO:0000255"
FT REPEAT 644..712
FT /note="Gelsolin-like 4"
FT /evidence="ECO:0000255"
FT DOMAIN 890..955
FT /note="HP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00595"
FT REGION 741..783
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..895
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..867
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 107343 MW; 1824027EE30EF6FA CRC64;
MSVSMKDLDP AFRGAGQKEG LEIWRIENFK PVPIPASSYG KFFMGDSYII LKTTALKNGS
LRHDIHYWIG KDTSQDESGT AAILTVELDA ALGGRAVQYR EIQGNETDKF LSYFRPCIMP
QPGGVASGFK HVEVNEQEHE TRLYVCTGNR VVHVKEVPFA RSSLNHDDIF ILDTKSKIFQ
FNGSNSSIQE RAKALEVVQY IKDTFHEGKC EVAAVEDGRL MADAEAGEFW GFFGGFAPLP
RRAPVEDNEK YEETVFKLLC FNQGKLEPIN YESLLHELLK TNKCYLLDCG VELFVWMGRT
TSLQERKSAS EAAEKLLSDD NRTKTHVIKV IEGFETVMFK SKFKEWPQTP DLKLSSEDGR
GKVAALLKRQ GLNVKGLMKA APAKEEPQAY IDCTGSLQVW RINDKDKILL PSADQSKFYT
GDCYIFQYMY PGDDKEECLI GSWFGKKSIE EDRVTAISLA SKMVESAKFQ AVQTRLYEGK
EPIQFFVIFQ SFQVFKGGLS SGYKKFIAEN GIDDDTYLED GLALFRIQGS GPENMQAIQV
DAAASSLNSS YSYILHDGNT VFTWTGNLTT SLDQEVVERQ LDIIKPNSQS RSQKEGSETD
QFWSLLGGKS EYPSQKIGRA NESDPHLFSC ILPKGNLKIK EIYHFTQDDL MTEDVFILDC
HSDIFVWVGQ QVDVKVRLQA LDIGEKFVKL DFLMENLSSD TPIFVIMEGS EPTFFTRFFT
WDSAKSLMHG NSYQRKLSIV KGGGSPALDK PKRRTPTYSG RSTVQDKSQR SRSMSFSPER
VRVRGRSPAF TALAANFESA NSRNLSTPPP VVKKLYPKSA TPDSSSAPSK SSATASLTGS
FDRPKSVKDG SELEKPKQEE DAKEGINTMT SRVESLTINE DVKENEPEDD EGLPVYPYDR
LITTAADPVT EIDVTRRETY LSSAEFKDKF GMTKEAFSKL PKWKQNRMKI ALQLF
