ID   VLP10_BORHE             Reviewed;         366 AA.
AC   P70900;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Variable large protein 10 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp10 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp10 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17733.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Beta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52037; AAB17733.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70900; -.
DR   SMR; P70900; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..366
FT                   /note="Variable large protein 10"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244502"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   366 AA;  37667 MW;  9D67C6383F3A02DE CRC64;
     MRKRISAIIM TLFMVLASCS NQLEAEKLAA ESKNTFFDSL VKIGQGFQDI FGILEMQLGD
     ALGFNAVKSG DKKSKVGEHF KKIGDGLTTT KDKLKELSNK ISEAKNANSS TIEAVKSAIN
     SASDVFEQLI TALTKLADTA KEAGDTNIGD NADAVPGAAE KTGVEAIIAG VKDIIGAAEK
     SGVKIEYGNA GDPIATAANT TDALAVLGGN TAKATQGAGD KLAFEVSKAD PWAIIDKIKN
     AKAADGIQLD AGEKDAGTLA ASNNNASANA GAESNAASSS SWLFLMQLSK GGKFSAAVAD
     AGAVKAAAVS AVNKVLGVLD FIIRKTVSSN LDKIREAVKG IKYSEITETD ATESGDAQPI
     TNKSSN