ID   VLP12_BORHE             Reviewed;         353 AA.
AC   P70901;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Variable large protein 12 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp12 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp12 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17734.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Beta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52038; AAB17734.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70901; -.
DR   SMR; P70901; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..353
FT                   /note="Variable large protein 12"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244503"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   353 AA;  36042 MW;  560F344C23D4C561 CRC64;
     MRKRISAIIM TLFMVLASCS NQLEAEKLAA ESKNTFFDSL VKIGQGFQDI FGIFGNAIGD
     ALGFNAVKSD DKRSKVGEHF EGVGKGLKDT KIKLDELLKE VTAAPHADTT EVKSVINSAS
     AVLTKLIDSV TKLAGAVGNT DIADGVSIAN GAAAEEASVK TVIEGVKEII DVATNSGVKI
     EKGNAGTAVA NANGPKAIIH NAQAAAGDAT KLADEVAKAD PWAMIDKIKN AKTKNGIAAA
     NDDAGQLATA TNAANNNGTA ATNADLAAAV ALKAMAKGGK FTQPAANEDG AVKAAAASAV
     NKVLGILDVI IRKAVNLELG KIKEAVKGIK YSEATGEATE SDTAQPITNK SSN