ID   VLP14_BORHE             Reviewed;         360 AA.
AC   P70905;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Variable large protein 14 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp14 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp14 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17738.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Beta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52148; AAB17738.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70905; -.
DR   SMR; P70905; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..360
FT                   /note="Variable large protein 14"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244504"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   360 AA;  36530 MW;  A69BE7C221806B23 CRC64;
     MRKRISAIIM TLFMVLASCS NQLEAEKLAA ESKNTFFDSL VKIGQGFQDI FGIFGNAIGD
     ALGFNAVKSG DKKSKIGEHF KKIGDGLTTT KDKLNELSGE ISEAKNANGS SIEAVKSAIN
     SASDVFEQLI TALTKLAGVA KEAGSTDIGD TASAAALARD KDGVEAIIAG IKAIIDVADK
     SGVNIEKGNA GGPVNAAANT DAPAALAANA AAGANSTAKL AAEVTKADPW AMIDKINSAK
     AAVGVQLDAN TNYGAGELAT GTPNQANGSK AATNADLAAA VALKAMAKGG KFSHAANEDG
     AVKAAAVSAV NKVLGVLDFI IRKTVSSNLD KIREAVKGIK YSEITETDAT ESGDAQPTTK