ID   VLP15_BORHE             Reviewed;         354 AA.
AC   P70902;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Variable large protein 15/16 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp15 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp16 {ECO:0000303|Ref.1, ECO:0000312|EMBL:AAB17735.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000303|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17735.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Delta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
CC   -!- CAUTION: Gene called vmp16 in DNA submission but vlp15 in nomenclature
CC       paper. {ECO:0000305}.
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DR   EMBL; U52039; AAB17735.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70902; -.
DR   SMR; P70902; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..354
FT                   /note="Variable large protein 15/16"
FT                   /id="PRO_0000244505"
FT   REGION          333..354
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..354
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   354 AA;  36563 MW;  0C14A71AD06D8EB4 CRC64;
     MRKRISAIIM TLFMVLVSCN SGGVAEDPKT VYLTSIANLG KGFLDVFVTF GDMVTGAFGI
     KADTKKSDIG KYFTDIEKTM TSVKKKLQDE VVKNGNYAKV KTVVAKFIEE VLDKIAAGAK
     EAAKGATGSD AIGNAVHNQD AVAADATSVN ALVKGIGEIV EVVLKDGEGD AGATKTGDTE
     KKSIGKLFAK KDDDRAQEAE ASAANASIGA VSGADILKAI AKSGEIADNN KNIEEAKDAA
     SIAAAKQTDD KKEIKDEAAK KDAVIAAGIA LRAMAKGGKF TAKQNEEKSA NAVNGAAASA
     VGKTLSTLII AIRNTVDSGL KTINEALATV KQEDKSVEAT NTAEATTSGQ QAKN