ID   VLP17_BORHE             Reviewed;         353 AA.
AC   P32777;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Variable large protein 17 {ECO:0000303|PubMed:9453591};
DE   AltName: Full=Variable major outer membrane lipoprotein 17;
DE   Flags: Precursor;
GN   Name=vlp17 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp17 {ECO:0000303|PubMed:1484486};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000303|PubMed:1484486}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RX   PubMed=1484486; DOI=10.1111/j.1365-2958.1992.tb02198.x;
RA   Restrepo B.I., Kitten T., Carter C.J., Infante D., Barbour A.G.;
RT   "Subtelomeric expression regions of Borrelia hermsii linear plasmids are
RT   highly polymorphic.";
RL   Mol. Microbiol. 6:3299-3311(1992).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Delta
CC       subfamily. {ECO:0000305}.
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DR   EMBL; L04788; AAA22963.1; -; Genomic_DNA.
DR   PIR; I40300; I40300.
DR   AlphaFoldDB; P32777; -.
DR   SMR; P32777; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000305"
FT   CHAIN           19..353
FT                   /note="Variable large protein 17"
FT                   /id="PRO_0000018088"
FT   REGION          332..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..353
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   353 AA;  36460 MW;  88FAB9B8C619AE91 CRC64;
     MRKRISAIIM TLFMVLVSCN SGGVAEDPKT VYLTSIANLG KGFLDVFVTF GDMVTGAFGI
     KADTKKSDIG KYFTDIESTM TSVKKKLQDE VAKNGNYPKV KTAVDEFVAI LGKIEKGAKE
     ASKGATGDVI IGNTVKNGDA VPGEATSVNS LVKGIKEIVG VVLKEGKADA DATKDDSKKD
     IGKLFTATTD ANRADNAAAQ AAAASIGAVT GADILQAIVQ SKENPVANST DGIEKATDAA
     EIAVAPAKDN KKEIKDGAKK DAVIAAGIAL RAMAKNGTFS IKNNEDAAVT TINSAAASAV
     NKILSTLIIA IRNTVDSGLK TINEALATVK QEDKSVEATN TAEATTSGQQ AKN