ID   VLP18_BORHE             Reviewed;         360 AA.
AC   P70906;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Variable large protein 18 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp18 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp18 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17739.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Alpha
CC       subfamily. {ECO:0000269|PubMed:9453591}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U52149; AAB17739.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70906; -.
DR   SMR; P70906; -.
DR   PRIDE; P70906; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           27..360
FT                   /note="Variable large protein 18"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244506"
FT   LIPID           27
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           27
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   360 AA;  36906 MW;  86204DE08F4EEA38 CRC64;
     MRKRISAIIN KLNISIMMMI VVLMIGCGQQ AVEAGKDGAR AATGGRSLSE VLMEVGKSAE
     NAFYSFMALV SDTLGLRVTK DTKKNEVGGY FNSLGGKLGK ASDELEEVAK KSEVEGAKDG
     PIAVAIRAAV DTAKTTLSTL KGHLESLKGI GDDKVVGWAE NDQQGIKPAD DGLNKFLNAL
     QSIVKAATDA GVLAPKAGNT TLTVNGVDNK DGAKVLAIDK PGAAVGEKAS LIVSAVSGEE
     ILASIVASKE GDQALGAAAD GTTTAMSFAK GGTKDNLSNA NTPKAAAVAG GIALRSLVKD
     GKLASHNDNS EKAVQAAGVI AANKLLVSVE DLIKKTVKNV LEKAKEKIDK ARAPKATGQQ