ID   VLP19_BORHE             Reviewed;         349 AA.
AC   P70903;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Variable large protein 19 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor; Fragment;
GN   Name=vlp19 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp19 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17736.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Gamma
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52040; AAB17736.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70903; -.
DR   SMR; P70903; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..>349
FT                   /note="Variable large protein 19"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244507"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   NON_TER         349
FT                   /evidence="ECO:0000312|EMBL:AAB17736.1"
SQ   SEQUENCE   349 AA;  35222 MW;  ED336CB12355E4BF CRC64;
     MRKRISAIIM TLFMVLVSCN SGGVAEDPQS KFLKSVIDLG NDFLNVFTSF GDIVSKVLGF
     STETKKSDVG AYFKTIQDTI QGTKDKLNKI VTDMKREGNP NASATETAVK TLIDNTLDKI
     IEGAKTVSDA IGDASDPIAN VAAQNAAGAA GTEVDKLVKG IKTIVDVVLK GVGSANAGDD
     KKAEDGNTAR TAAAGDGEAG KLFTAGAGAA GDANNAKKVA ADAAKAVGAV TGADILQAMI
     KDNGDAAKLA TAQNAGAAPK DGAIAGGIAL RVMAKGGKFA GPSAAADDAV TAIKGAAISA
     ITKALDTLTI AIRKTIDAGL KTVKEAMKIN ANDTPISPEQ NTPKATTNN