ID   VLP23_BORHE             Reviewed;         345 AA.
AC   P70904;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Variable large protein 23 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp23 {ECO:0000303|PubMed:9453591};
GN   Synonyms=vmp23 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17737.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Delta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52041; AAB17737.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70904; -.
DR   SMR; P70904; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..345
FT                   /note="Variable large protein 23"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244508"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   345 AA;  35292 MW;  187FD3623EAF5D5D CRC64;
     MRKRISAIIM TLFMVLVSCN SGGVAEDPKT VYLTSIANLG KGFLDVFVTF GDMVAGAFGI
     KADTKKSDIG KYFNDIEKTM TTVKKRLQDE VAKNGNYVKV KEVVDKFVAD VLDKIAAGAK
     KQLRATGDAA IGMLLNEDAA PAEVASVNSL VKGIKEIVGV VLKDNEGDAA ATKTADAEKK
     SVGKLLGKGA ADGTETQAAA ASASIGAITG ADILQAIAKS GKAGAGEIKI EEAKNAAEIA
     AAKADSKDLA IDSAKKDAVI AAGIALRAMA KDGKFAAKNN EEKSANAVNG AAASAVGKTL
     STLIIAIRNT VDSGLKTINE ALATVKQEDK SAEATNPAEA TTSGQ