ID   VLP4_BORHE              Reviewed;         350 AA.
AC   P70897;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Variable large protein 4 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp4 {ECO:0000303|PubMed:9453591}; Synonyms=vmp4 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB09432.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Delta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U51926; AAB09432.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70897; -.
DR   SMR; P70897; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..350
FT                   /note="Variable large protein 4"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244499"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   350 AA;  36745 MW;  2FA71BC2DAFA1307 CRC64;
     MRRRISAIIM TLFMVLVSCN SGGVAEDPKT VYLTSIANLG KGFLDVFVTF GDMVAGAFGI
     RADTKKSDIG KYFNDIEKTM TTVKKRLQDE VAKNGNYVKV KEVVDKFVAD VLDKIAAGAK
     EAAKGATGDD KIRKCYFCWA WSQSADKDSV ISLVKGIKTI VDAVLKDKGD AGATKTGEDK
     KDIGNLFIND AGKDGSKREN IAKAAASIGS VTGADILQAI IKSKENPNAD SVNGIEKATD
     AAEIAIVPAV NKTEIKEDTA KKDAVIAAGI ALRAMAKDGK FAAKNEEKSA NAVNGAAASA
     VGKTLSTLII AIRNTVDSGL KTINEALATV KQEDKSAEAT NPAEATTSGQ