ID   VLP5_BORHE              Reviewed;         340 AA.
AC   P70898;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Variable large protein 5 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp5 {ECO:0000303|PubMed:9453591}; Synonyms=vmp5 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17731.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Gamma
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52035; AAB17731.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70898; -.
DR   SMR; P70898; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..340
FT                   /note="Variable large protein 5"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244500"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   340 AA;  34482 MW;  631E7B2DA139B7E5 CRC64;
     MRKRISAIIM TLFMVLVSCN SGGVAEDPQS KFLKSAIDLG NDFLNVFTSF GDIVSKVLGF
     STETKKSDVG AYFKTIQDTI QGTKDKLNKI VTDMKREGNP NASATETAVK TLIDNTLDKI
     IEGSKTVSDA IGDASDPIAN VGANNAAGVA GTGIESLTKG IKAIVDVVLG KEGNAEAGTD
     KKAEDLSART AAGNGEAGKL FAANAGDDAN AKKVAADAAK AVGAVTGADI LQAMVKNGAN
     AAADAAKANA KDGTIAGAIA LTVMAKGGKF AGPTADSADY VTVAKGAAVS AITKALDTLT
     IAIRKTIDAG LKTVKEAMKI NANDTPISPE QNTPKATTNN