ID   VLP9_BORHE              Reviewed;         358 AA.
AC   P70899;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Variable large protein 9 {ECO:0000303|PubMed:9453591};
DE   Flags: Precursor;
GN   Name=vlp9 {ECO:0000303|PubMed:9453591}; Synonyms=vmp9 {ECO:0000303|Ref.1};
OS   Borrelia hermsii.
OG   Plasmid {ECO:0000269|PubMed:9453591}.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=140;
RN   [1] {ECO:0000312|EMBL:AAB17732.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 35209 / HS1;
RA   Restrepo B.I., Carter C.J., Infante D., Barbour A.G.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   NOMENCLATURE.
RX   PubMed=9453591; DOI=10.1128/iai.66.2.432-440.1998;
RA   Hinnebusch B.J., Barbour A.G., Restrepo B.I., Schwan T.G.;
RT   "Population structure of the relapsing fever spirochete Borrelia hermsii as
RT   indicated by polymorphism of two multigene families that encode immunogenic
RT   outer surface lipoproteins.";
RL   Infect. Immun. 66:432-440(1998).
CC   -!- FUNCTION: The Vlp and Vsp proteins are antigenically distinct proteins,
CC       only one vlp or vsp gene is transcriptionally active at any one time.
CC       Switching between these genes is a mechanism of host immune response
CC       evasion. {ECO:0000250|UniProtKB:P21875}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000250|UniProtKB:P21875}; Lipid-anchor.
CC   -!- MISCELLANEOUS: Genes for both Vlp and Vsp families are on (usually)
CC       unnamed linear plasmids in B.hermsii HS1. {ECO:0000305|PubMed:9453591}.
CC   -!- SIMILARITY: Belongs to the variable large protein (Vlp) family. Beta
CC       subfamily. {ECO:0000269|PubMed:9453591}.
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DR   EMBL; U52036; AAB17732.1; -; Genomic_DNA.
DR   AlphaFoldDB; P70899; -.
DR   SMR; P70899; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000680; Borrelia_lipo.
DR   Pfam; PF00921; Lipoprotein_2; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           19..358
FT                   /note="Variable large protein 9"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000244501"
FT   LIPID           19
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
FT   LIPID           19
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255, ECO:0000305"
SQ   SEQUENCE   358 AA;  36918 MW;  548DAEBC8BAD0661 CRC64;
     MRKRISAIIM TLFMVLASCS NQLEAEKLAA ESKNTFFDSL VKIGQGFQDI FGIFGNAIGD
     ALGFNAVKSD DKRSKVGEHF EGVGEGLKDT KIKLDELLKE VTAAPHADTT EVKSVINNAG
     AVLTKLIDSV AKLAGATKSE APIGDAGTAQ AAAATPADIA DVNTVIEGVK KIIEVAEKSG
     VKIEKGTAGA QVANANGPKV LTNNAQADAN SGPALAAEVD KADPWAMIDK IKMLKLLLHL
     LHLRLMMTPG QLATGSANAA NNGTAATNAD LAAAVALKAI TKGGKFTQPA ANEDGAVKVA
     AASAVNKVLG ILDAIIRKAV NLELGKIKEA VKGIKYSEIT GEATESGIDQ PITNKSSN