ID   VLPA_MESHY              Reviewed;         176 AA.
AC   P29228;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Variant surface antigen A;
DE   AltName: Full=VlpA prolipoprotein;
DE   Flags: Precursor;
GN   Name=vlpA;
OS   Mesomycoplasma hyorhinis (Mycoplasma hyorhinis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mesomycoplasma.
OX   NCBI_TaxID=2100;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SK76;
RX   PubMed=1721868; DOI=10.1002/j.1460-2075.1991.tb04983.x;
RA   Yogev D., Rosengarten R., Watson-Mckown R., Wise K.S.;
RT   "Molecular basis of Mycoplasma surface antigenic variation: a novel set of
RT   divergent genes undergo spontaneous mutation of periodic coding regions and
RT   5' regulatory sequences.";
RL   EMBO J. 10:4069-4079(1991).
RN   [2]
RP   SEQUENCE REVISION.
RA   Wise K.S.;
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the antigenic diversity for host adaptation.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: The numbers of repeats can vary and is one of the basis
CC       of the antigenic diversity.
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DR   EMBL; X62936; CAA44708.2; -; Genomic_DNA.
DR   PIR; S18651; S18651.
DR   AlphaFoldDB; P29228; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006743; VlpA_repeat.
DR   Pfam; PF04649; VlpA_repeat; 2.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Repeat; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000305"
FT   CHAIN           30..176
FT                   /note="Variant surface antigen A"
FT                   /id="PRO_0000018213"
FT   REPEAT          123..135
FT                   /note="1"
FT   REPEAT          155..167
FT                   /note="2"
FT   REPEAT          168..176
FT                   /note="3; truncated"
FT   REGION          33..176
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..176
FT                   /note="2.5 X 13 AA repeats"
FT   LIPID           30
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           30
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   176 AA;  17441 MW;  6F0FDCF616FB9A9A CRC64;
     MKKSIFSKKL LVSFGSLVAL AAIPLIAISC GQTDNNSSQS QQPGSGTTNT SGGTNSSGST
     NGTAGTNSSG STNGSGNGSN SETNTGNKTT SESNSGSSTG SQAGTTTNTG SGSNSESGMN
     SEKTENTQQS EAPGTNTGNK TTSESNSESG MNSEKTENTQ QSEAPGTKTE NTQHTS