ID   VLPD_MESHY              Reviewed;         168 AA.
AC   Q49536; O05665;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Variant surface antigen D;
DE   AltName: Full=VlpD prolipoprotein;
DE   Flags: Precursor;
GN   Name=vlpD;
OS   Mesomycoplasma hyorhinis (Mycoplasma hyorhinis).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mesomycoplasma.
OX   NCBI_TaxID=2100;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND POSSIBLE EXPRESSION.
RC   STRAIN=GDL-1;
RX   PubMed=7559353; DOI=10.1128/jb.177.19.5636-5643.1995;
RA   Yogev D., Watson-Mckown R., Rosengarten R., Im J., Wise K.S.;
RT   "Increased structural and combinatorial diversity in an extended family of
RT   genes encoding Vlp surface proteins of Mycoplasma hyorhinis.";
RL   J. Bacteriol. 177:5636-5643(1995).
RN   [2]
RP   SEQUENCE REVISION TO C-TERMINUS.
RA   Watson-Mckown R.;
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the antigenic diversity for host adaptation.
CC       Expression in E.coli of a construct containing vlpD, vlpE, and vlpF
CC       yields antigenically distinguishable products corresponding to each
CC       gene. {ECO:0000305|PubMed:7559353}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: The numbers of repeats can vary and is one of the basis
CC       of the antigenic diversity.
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DR   EMBL; U35016; AAC45470.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q49536; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Repeat; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000305"
FT   CHAIN           30..168
FT                   /note="Variant surface antigen D"
FT                   /id="PRO_0000018216"
FT   REPEAT          81..92
FT                   /note="1"
FT   REPEAT          93..104
FT                   /note="2"
FT   REPEAT          105..116
FT                   /note="3"
FT   REPEAT          117..128
FT                   /note="4"
FT   REPEAT          129..140
FT                   /note="5"
FT   REPEAT          141..152
FT                   /note="6"
FT   REPEAT          153..164
FT                   /note="7"
FT   REGION          33..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          81..164
FT                   /note="7 X 12 AA tandem repeats"
FT   LIPID           30
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           30
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   168 AA;  16571 MW;  B8E1870F60ABFD5E CRC64;
     MKKSIFSKKL LVSFGSLVTL AAIPLIAISC GQTNTDQSQQ PGSGSTTGGQ SGTTTGTDST
     TGGQTGSESG TTTGGQTGTT TGGQSDSTST SKEQGSSDST STSKEQGSSD STSTSKEQGS
     SDSTSTSKEQ GSSDSTSTSK EQGSSDSTST SKEQGSSDST STSNMNTR