ID   VLTF1_VACCA             Reviewed;         260 AA.
AC   O57198;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   07-APR-2021, entry version 51.
DE   RecName: Full=Late transcription factor 1;
DE            Short=VLTF-1;
DE   AltName: Full=Trans-activator protein GK1;
GN   Name=VLTF1; OrderedLocusNames=MVA078R, ACAM3000_MVA_078; ORFNames=G8R;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with RNA polymerase to initiate transcription from
CC       late gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the late transcription factors VLTF-2 and VLTF-
CC       3. Interacts with the late transcription elongation factor H5/VLTF-4.
CC       Interacts with itself (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the intermediate phase of the viral replicative
CC       cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae VLTF-1 family.
CC       {ECO:0000305}.
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DR   EMBL; U94848; AAB96496.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10476.1; -; Genomic_DNA.
DR   PIR; T37354; T37354.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005022; Pox_TAP.
DR   Pfam; PF03355; Pox_TAP; 1.
PE   2: Evidence at transcript level;
KW   Activator; Late protein; Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="Late transcription factor 1"
FT                   /id="PRO_0000099165"
SQ   SEQUENCE   260 AA;  29941 MW;  D2407C562CEF4D69 CRC64;
     MSIRIKIDKL RQIVAYFSEF SEEVSINVDS TDELMYIFAA LGGSVNIWAI IPLSASVFYR
     GAENIVFNLP VSKVKSCLCS FHNDAIIDIE PDLENNLVKL SSYHVVSVDC NKELMPIRTD
     TTICLSIDQK KSYVFNFHKY EEKCCGRTVI HLEWLLGFIK CISQHQHLAI MFKDDNIIMK
     TPGNTDAFSR EYSMTECSQE LQKFSFKIAI SSLNKLRGFK KRVNVFETRI VMDNDDNILG
     MLFSDRVQSF KINIFMTFLD