ID   VLTF1_VACCC             Reviewed;         260 AA.
AC   P68612; P21029;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Late transcription factor 1;
DE            Short=VLTF-1;
DE   AltName: Full=Trans-activator protein GK1;
GN   Name=VLTF1; ORFNames=G8R;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Associates with RNA polymerase to initiate transcription from
CC       late gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the late transcription factors VLTF-2 and VLTF-
CC       3. Interacts with the late transcription elongation factor H5/VLTF-4.
CC       Interacts with itself (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the intermediate phase of the viral replicative
CC       cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae VLTF-1 family.
CC       {ECO:0000305}.
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DR   EMBL; M35027; AAA48074.1; -; Genomic_DNA.
DR   PIR; A35347; A35347.
DR   PRIDE; P68612; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005022; Pox_TAP.
DR   Pfam; PF03355; Pox_TAP; 1.
PE   2: Evidence at transcript level;
KW   Activator; Late protein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..260
FT                   /note="Late transcription factor 1"
FT                   /id="PRO_0000099166"
SQ   SEQUENCE   260 AA;  29911 MW;  D2407C4A5CEF4D69 CRC64;
     MSIRIKIDKL RQIVAYFSEF SEEVSINVDS TDELMYIFAA LGGSVNIWAI IPLSASVFYR
     GAENIVFNLP VSKVKSCLCS FHNDAIIDIE PDLENNLVKL SSYHVVSVDC NKELMPIRTD
     TTICLSIDQK KSYVFNFHKY EEKCCGRTVI HLEWLLGFIK CISQHQHLAI MFKDDNIIMK
     TPGNTDAFSR EYSMTECSQE LQKFSFKIAI SSLNKLRGFK KRVNVFETRI VMDNDDNILG
     MLFSDRVQSF KINIFMAFLD