ID   VLTF1_VAR67             Reviewed;         260 AA.
AC   P32990;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Late transcription factor 1;
DE            Short=VLTF-1;
DE   AltName: Full=Trans-activator protein GK1;
GN   Name=VLTF1; ORFNames=G8R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8109158; DOI=10.1016/0168-1702(93)90093-3;
RA   Shchelkunov S.N., Blinov V.M., Resenchuk S.M., Totmenin A.V.,
RA   Sandakhchiev L.S.;
RT   "Analysis of the nucleotide sequence of a 43 kbp segment of the genome of
RT   variola virus India-1967 strain.";
RL   Virus Res. 30:239-258(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8383392; DOI=10.1016/0168-1702(93)90110-9;
RA   Shchelkunov S.N., Blinov V.M., Totmenin A.V., Marennikova S.S.,
RA   Kolykhalov A.A., Frolov I.V., Chizhikov V.E., Gytorov V.V., Gashikov P.V.,
RA   Belanov E.F., Belavin P.A., Resenchuk S.M., Andzhaparidze O.G.,
RA   Sandakhchiev L.S.;
RT   "Nucleotide sequence analysis of variola virus HindIII M, L, I genome
RT   fragments.";
RL   Virus Res. 27:25-35(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Shchelkunov S.N., Sosnovtsev S.V., Totmenin A.V., Resenchuk S.M.,
RA   Blinov V.M., Sandakhchiev L.S.;
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Associates with RNA polymerase to initiate transcription from
CC       late gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the late transcription factors VLTF-2 and VLTF-
CC       3. Interacts with the late transcription elongation factor H5/VLTF-4.
CC       Interacts with itself (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the intermediate phase of the viral replicative
CC       cycle.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae VLTF-1 family.
CC       {ECO:0000305}.
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DR   EMBL; X67119; CAA47570.1; -; Genomic_DNA.
DR   EMBL; X69198; CAA49012.1; -; Genomic_DNA.
DR   EMBL; X76267; CAA53876.1; -; Genomic_DNA.
DR   PIR; E36844; E36844.
DR   PIR; E72159; E72159.
DR   RefSeq; NP_042115.1; NC_001611.1.
DR   GeneID; 1486437; -.
DR   KEGG; vg:1486437; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR005022; Pox_TAP.
DR   Pfam; PF03355; Pox_TAP; 1.
PE   2: Evidence at transcript level;
KW   Activator; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..260
FT                   /note="Late transcription factor 1"
FT                   /id="PRO_0000099168"
SQ   SEQUENCE   260 AA;  29941 MW;  CFEB0C5E19FB1C2C CRC64;
     MSIRIKIDKL RQIVAYFSEF SEEVSINVDS TDELMYIFAA LGGSVNIWAI IPLSASVFYR
     GAENIVFNLP VSKVKSCLCS FHNDAIIDIE PDLENNLVKL SSYHVVSVDC NKELMPIRTD
     TTICLSIDQK KSYVFNFHKY EEKCCGRTVI HLEWLLGFIK CISQHQHLTI MFKDDNIIMK
     TPGNTDAFSR EYSMTECSQE LQKFSFKIAI SSLNKLRGFK KRVNVFETRI VMDNDDNILG
     MLFSDRVQSF KINIFMAFLD