ID   VLTF2_VAR67             Reviewed;         150 AA.
AC   P0DSV3; P33814;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   12-AUG-2020, entry version 6.
DE   RecName: Full=Viral late gene transcription factor 2;
DE            Short=VLTF-2;
DE   AltName: Full=Trans-activator protein A1;
GN   Name=VLTF2; ORFNames=A1L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with itself. Interacts with the late transcription
CC       factors VLTF-1 (By similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Intermediate stages of infection.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae VLTF-2 family.
CC       {ECO:0000305}.
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DR   EMBL; X69198; CAA49045.1; -; Genomic_DNA.
DR   PIR; B36848; B36848.
DR   RefSeq; NP_042148.1; NC_001611.1.
DR   GeneID; 1486495; -.
DR   KEGG; vg:1486495; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR004975; Poxvirus_VLTF2.
DR   InterPro; IPR010507; Znf_MYM.
DR   Pfam; PF03295; Pox_TAA1; 1.
DR   Pfam; PF06467; zf-FCS; 1.
PE   2: Evidence at transcript level;
KW   Activator; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..150
FT                   /note="Viral late gene transcription factor 2"
FT                   /id="PRO_0000099173"
SQ   SEQUENCE   150 AA;  16966 MW;  1DE0A936061E6256 CRC64;
     MAKRVSLPDV VISAPKAVFK PAKEEALACI LPKYYKSMAD MSIKTNSVID KCWFCNQDLV
     FRPISIETFK GGEVGYFCSK ICRDSLASMV KSHVALREEP KISLLPLVFY EDKEKVINTI
     NLLRDKDGVY GSCYFKENSQ IIDISLRSLL