ID   VLTF2_VARV              Reviewed;         150 AA.
AC   P0DSV4; P33814;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 11.
DE   RecName: Full=Viral late gene transcription factor 2;
DE            Short=VLTF-2;
DE   AltName: Full=Trans-activator protein A1;
GN   Name=VLTF2; ORFNames=A1L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Shchelkunov S.N., Totmenin A.V., Resenchuk S.M., Blinov V.M.,
RA   Sandakhchiev L.S.;
RT   "XhoI-M DNA fragment of Variola minor virus strain Garcia-1966.";
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with itself. Interacts with the late transcription
CC       factors VLTF-1 (By similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Intermediate stages of infection.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae VLTF-2 family.
CC       {ECO:0000305}.
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DR   EMBL; L22579; AAA60852.1; -; Genomic_DNA.
DR   EMBL; X76262; CAA53826.1; -; Genomic_DNA.
DR   PIR; F72163; F72163.
DR   PIR; T28542; T28542.
DR   RefSeq; NP_042148.1; NC_001611.1.
DR   GeneID; 1486495; -.
DR   KEGG; vg:1486495; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR004975; Poxvirus_VLTF2.
DR   InterPro; IPR010507; Znf_MYM.
DR   Pfam; PF03295; Pox_TAA1; 1.
DR   Pfam; PF06467; zf-FCS; 1.
PE   2: Evidence at transcript level;
KW   Activator; Transcription; Transcription regulation.
FT   CHAIN           1..150
FT                   /note="Viral late gene transcription factor 2"
FT                   /id="PRO_0000448138"
SQ   SEQUENCE   150 AA;  16966 MW;  1DE0A936061E6256 CRC64;
     MAKRVSLPDV VISAPKAVFK PAKEEALACI LPKYYKSMAD MSIKTNSVID KCWFCNQDLV
     FRPISIETFK GGEVGYFCSK ICRDSLASMV KSHVALREEP KISLLPLVFY EDKEKVINTI
     NLLRDKDGVY GSCYFKENSQ IIDISLRSLL