ID   VLTF3_VACCA             Reviewed;         224 AA.
AC   Q76ZR2;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 55.
DE   RecName: Full=Viral late gene transcription factor 3;
DE            Short=VLTF-3;
DE   AltName: Full=Trans-activator protein A2;
GN   Name=VLTF3; OrderedLocusNames=MVA112L, ACAM3000_MVA_112;
OS   Vaccinia virus (strain Ankara) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=126794;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9601507; DOI=10.1006/viro.1998.9123;
RA   Antoine G., Scheiflinger F., Dorner F., Falkner F.G.;
RT   "The complete genomic sequence of the modified vaccinia Ankara strain:
RT   comparison with other orthopoxviruses.";
RL   Virology 244:365-396(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Acambis 3000;
RA   Esposito J.J., Frace M., Sammons S.A., Olsen-Rasmussen M.S., Osborne J.,
RA   Khristova M., Wohlhueter R.M.;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters.
CC   -!- SUBUNIT: Interacts with the late transcription elongation factor
CC       H5/VLTF-4. Interacts with the late transcription factors VLTF-1 (By
CC       similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Intermediate stages of infection.
CC   -!- SIMILARITY: Belongs to the nucleo-cytoplasmic large DNA viruses
CC       (NCLDVs) VLTF-3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U94848; AAB96455.1; -; Genomic_DNA.
DR   EMBL; AY603355; AAT10510.1; -; Genomic_DNA.
DR   RefSeq; YP_233002.1; NC_006998.1.
DR   SMR; Q76ZR2; -.
DR   DNASU; 3707518; -.
DR   GeneID; 3707518; -.
DR   KEGG; vg:3707518; -.
DR   Proteomes; UP000159908; Genome.
DR   Proteomes; UP000172909; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046782; P:regulation of viral transcription; IEA:InterPro.
DR   InterPro; IPR007031; Poxvirus_VLTF3.
DR   InterPro; IPR014900; VLTF-3_Zn_ribbon.
DR   Pfam; PF08792; A2L_zn_ribbon; 1.
DR   Pfam; PF04947; Pox_VLTF3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Late protein; Metal-binding; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..224
FT                   /note="Viral late gene transcription factor 3"
FT                   /id="PRO_0000099175"
FT   ZN_FING         6..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  26289 MW;  B2406504F65885FB CRC64;
     MNLRLCSGCR HNGIVSEQGY EYCIFCESVF QKCTKVQKKS NFHVSNKLIH LRNVLRRLLS
     HQCSGEIISE LLDIMEKNQI STDDVDANFV SSFLKANERI NKKDYKLVFE IINQVKDEKL
     NLSTEKINEV VEIFKHLVFF CQENTPSKTI NYSFFLDKIF DITSVTKNLK PQTVKNYTKN
     NSNQLVWENF LAHMRSKKRV TMVEDYGHEY VFVDERFSTC SLEV