ID   VLTF3_VACCC             Reviewed;         224 AA.
AC   P68318; P07609;
DT   01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1988, sequence version 1.
DT   23-FEB-2022, entry version 56.
DE   RecName: Full=Viral late gene transcription factor 3;
DE            Short=VLTF-3;
DE   AltName: Full=Trans-activator protein A2;
GN   Name=VLTF3; ORFNames=A2L;
OS   Vaccinia virus (strain Copenhagen) (VACV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10249;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=2219722; DOI=10.1016/0042-6822(90)90294-2;
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "The complete DNA sequence of vaccinia virus.";
RL   Virology 179:247-266(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Goebel S.J., Johnson G.P., Perkus M.E., Davis S.W., Winslow J.P.,
RA   Paoletti E.;
RT   "Appendix to 'The complete DNA sequence of vaccinia virus'.";
RL   Virology 179:517-563(1990).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters.
CC   -!- SUBUNIT: Interacts with the late transcription elongation factor
CC       H5/VLTF-4. Interacts with the late transcription factors VLTF-1 (By
CC       similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P68318; P98179: RBM3; Xeno; NbExp=2; IntAct=EBI-7366338, EBI-2949699;
CC       P68318; P07242: VACWR103; Xeno; NbExp=2; IntAct=EBI-7366338, EBI-7272435;
CC       P68318; P68613: VLTF1; Xeno; NbExp=3; IntAct=EBI-7366338, EBI-7273218;
CC   -!- DEVELOPMENTAL STAGE: Intermediate stages of infection.
CC   -!- SIMILARITY: Belongs to the nucleo-cytoplasmic large DNA viruses
CC       (NCLDVs) VLTF-3 family. {ECO:0000305}.
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DR   EMBL; M35027; AAA48117.1; -; Genomic_DNA.
DR   PIR; B23768; WMVZR1.
DR   SMR; P68318; -.
DR   IntAct; P68318; 4.
DR   MINT; P68318; -.
DR   Proteomes; UP000008269; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046782; P:regulation of viral transcription; IEA:InterPro.
DR   InterPro; IPR007031; Poxvirus_VLTF3.
DR   InterPro; IPR014900; VLTF-3_Zn_ribbon.
DR   Pfam; PF08792; A2L_zn_ribbon; 1.
DR   Pfam; PF04947; Pox_VLTF3; 1.
PE   1: Evidence at protein level;
KW   Activator; Late protein; Metal-binding; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..224
FT                   /note="Viral late gene transcription factor 3"
FT                   /id="PRO_0000099176"
FT   ZN_FING         6..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  26289 MW;  B2406504F65885FB CRC64;
     MNLRLCSGCR HNGIVSEQGY EYCIFCESVF QKCTKVQKKS NFHVSNKLIH LRNVLRRLLS
     HQCSGEIISE LLDIMEKNQI STDDVDANFV SSFLKANERI NKKDYKLVFE IINQVKDEKL
     NLSTEKINEV VEIFKHLVFF CQENTPSKTI NYSFFLDKIF DITSVTKNLK PQTVKNYTKN
     NSNQLVWENF LAHMRSKKRV TMVEDYGHEY VFVDERFSTC SLEV