ID   VLTF3_VAR67             Reviewed;         224 AA.
AC   P0DOT5; P07609; P68320;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 7.
DE   RecName: Full=Viral late gene transcription factor 3;
DE            Short=VLTF-3;
DE   AltName: Full=Trans-activator protein A2;
GN   Name=VLTF3; ORFNames=A2L;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters.
CC   -!- SUBUNIT: Interacts with the late transcription elongation factor
CC       H5/VLTF-4. Interacts with the late transcription factors VLTF-1 (By
CC       similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Intermediate stages of infection.
CC   -!- SIMILARITY: Belongs to the nucleo-cytoplasmic large DNA viruses
CC       (NCLDVs) VLTF-3 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49046.1; -; Genomic_DNA.
DR   PIR; C36848; C36848.
DR   RefSeq; NP_042149.1; NC_001611.1.
DR   SMR; P0DOT5; -.
DR   GeneID; 1486506; -.
DR   KEGG; vg:1486506; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046782; P:regulation of viral transcription; IEA:InterPro.
DR   InterPro; IPR007031; Poxvirus_VLTF3.
DR   InterPro; IPR014900; VLTF-3_Zn_ribbon.
DR   Pfam; PF08792; A2L_zn_ribbon; 1.
DR   Pfam; PF04947; Pox_VLTF3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Late protein; Metal-binding; Reference proteome; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..224
FT                   /note="Viral late gene transcription factor 3"
FT                   /id="PRO_0000099178"
FT   ZN_FING         6..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  26289 MW;  B2406504F65885FB CRC64;
     MNLRLCSGCR HNGIVSEQGY EYCIFCESVF QKCTKVQKKS NFHVSNKLIH LRNVLRRLLS
     HQCSGEIISE LLDIMEKNQI STDDVDANFV SSFLKANERI NKKDYKLVFE IINQVKDEKL
     NLSTEKINEV VEIFKHLVFF CQENTPSKTI NYSFFLDKIF DITSVTKNLK PQTVKNYTKN
     NSNQLVWENF LAHMRSKKRV TMVEDYGHEY VFVDERFSTC SLEV