ID   VLTF3_VARV              Reviewed;         224 AA.
AC   P0DOT6; P07609; P68320;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 12.
DE   RecName: Full=Viral late gene transcription factor 3;
DE            Short=VLTF-3;
DE   AltName: Full=Trans-activator protein A2;
GN   Name=VLTF3; ORFNames=A2L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Shchelkunov S.N., Totmenin A.V., Resenchuk S.M., Blinov V.M.,
RA   Sandakhchiev L.S.;
RT   "XhoI-M DNA fragment of Variola minor virus strain Garcia-1966.";
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts with RNA polymerase to initiate transcription from late
CC       gene promoters.
CC   -!- SUBUNIT: Interacts with the late transcription elongation factor
CC       H5/VLTF-4. Interacts with the late transcription factors VLTF-1 (By
CC       similarity). {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Intermediate stages of infection.
CC   -!- SIMILARITY: Belongs to the nucleo-cytoplasmic large DNA viruses
CC       (NCLDVs) VLTF-3 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22579; AAA60853.1; -; Genomic_DNA.
DR   EMBL; X76262; CAA53827.1; -; Genomic_DNA.
DR   PIR; G72163; G72163.
DR   PIR; T28543; T28543.
DR   RefSeq; NP_042149.1; NC_001611.1.
DR   SMR; P0DOT6; -.
DR   GeneID; 1486506; -.
DR   KEGG; vg:1486506; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046782; P:regulation of viral transcription; IEA:InterPro.
DR   InterPro; IPR007031; Poxvirus_VLTF3.
DR   InterPro; IPR014900; VLTF-3_Zn_ribbon.
DR   Pfam; PF08792; A2L_zn_ribbon; 1.
DR   Pfam; PF04947; Pox_VLTF3; 1.
PE   2: Evidence at transcript level;
KW   Activator; Late protein; Metal-binding; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..224
FT                   /note="Viral late gene transcription factor 3"
FT                   /id="PRO_0000448130"
FT   ZN_FING         6..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   224 AA;  26289 MW;  B2406504F65885FB CRC64;
     MNLRLCSGCR HNGIVSEQGY EYCIFCESVF QKCTKVQKKS NFHVSNKLIH LRNVLRRLLS
     HQCSGEIISE LLDIMEKNQI STDDVDANFV SSFLKANERI NKKDYKLVFE IINQVKDEKL
     NLSTEKINEV VEIFKHLVFF CQENTPSKTI NYSFFLDKIF DITSVTKNLK PQTVKNYTKN
     NSNQLVWENF LAHMRSKKRV TMVEDYGHEY VFVDERFSTC SLEV