ID   VLYS_BPCP1              Reviewed;         134 AA.
AC   Q38008;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 80.
DE   RecName: Full=Holin;
DE   AltName: Full=Lysis protein;
GN   Name=CPH1; Synonyms=21;
OS   Streptococcus phage Cp-1 (Bacteriophage Cp-1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Salasmaviridae; Cepunavirus.
OX   NCBI_TaxID=10747;
OH   NCBI_TaxID=1313; Streptococcus pneumoniae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8648702; DOI=10.1128/jvi.70.6.3678-3687.1996;
RA   Martin A.C., Lopez R., Garcia P.;
RT   "Analysis of the complete nucleotide sequence and functional organization
RT   of the genome of Streptococcus pneumoniae bacteriophage Cp-1.";
RL   J. Virol. 70:3678-3687(1996).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=9440507; DOI=10.1128/jb.180.2.210-217.1998;
RA   Martin A.C., Lopez R., Garcia P.;
RT   "Functional analysis of the two-gene lysis system of the pneumococcal phage
RT   Cp-1 in homologous and heterologous host cells.";
RL   J. Bacteriol. 180:210-217(1998).
CC   -!- FUNCTION: Produces a lesion in the cytoplasmic membrane allowing the
CC       phage lysosyme to attack the peptidoglycan.
CC   -!- SUBCELLULAR LOCATION: Host membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the bacteriophage holin family. Cp-1 holin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; Z47794; CAA87743.1; -; Genomic_DNA.
DR   RefSeq; NP_044836.1; NC_001825.1.
DR   TCDB; 1.E.16.1.1; the cph1 holin (cph1 holin) family.
DR   GeneID; 1261217; -.
DR   KEGG; vg:1261217; -.
DR   Proteomes; UP000009089; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR006480; Phage_holin_4_1.
DR   Pfam; PF05105; Phage_holin_4_1; 1.
DR   TIGRFAMs; TIGR01593; holin_tox_secr; 1.
PE   1: Evidence at protein level;
KW   Cytolysis; Host cell lysis by virus; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Viral release from host cell.
FT   CHAIN           1..134
FT                   /note="Holin"
FT                   /id="PRO_0000172857"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   134 AA;  15510 MW;  0CD547BC215D7E5F CRC64;
     MLYNIMLEVA KGDYITILFA LILFDFITGF LKAWKWKVTD SWTGLKGVIK HTLTFIFYYF
     VAVFLTYIHA MAVGQILLVI INLYYALSIM ENLAVMGVFI PKFMTARVQE ELQKYTAQLD
     AGKDLLEEFK GEKK