VLYS_BPPH1
ID VLYS_BPPH1 Reviewed; 135 AA.
AC Q9ZXD8;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 23-FEB-2022, entry version 75.
DE RecName: Full=Probable holin;
DE AltName: Full=Lysis protein;
GN Name=45;
OS Bacillus phage phi105 (Bacteriophage phi-105).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Siphoviridae; Spizizenvirus; Bacillus virus phi105.
OX NCBI_TaxID=10717;
OH NCBI_TaxID=1423; Bacillus subtilis.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Kobayashi K., Okamura K., Inoue T., Sato T., Kobayashi Y.;
RT "Complete nucleotide sequence of Bacillus subtilis phage phi-105.";
RL Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Produces a lesion in the cytoplasmic membrane allowing the
CC phage lysosyme to attack the peptidoglycan. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the bacteriophage holin family. Cp-1 holin
CC subfamily. {ECO:0000305}.
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DR EMBL; AB016282; BAA36651.1; -; Genomic_DNA.
DR PIR; T13534; T13534.
DR RefSeq; NP_690778.1; NC_004167.1.
DR GeneID; 955202; -.
DR KEGG; vg:955202; -.
DR Proteomes; UP000008338; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR InterPro; IPR006480; Phage_holin_4_1.
DR Pfam; PF05105; Phage_holin_4_1; 1.
DR TIGRFAMs; TIGR01593; holin_tox_secr; 1.
PE 3: Inferred from homology;
KW Cytolysis; Host cell lysis by virus; Host membrane; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix;
KW Viral release from host cell.
FT CHAIN 1..135
FT /note="Probable holin"
FT /id="PRO_0000172858"
FT TRANSMEM 24..41
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..84
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 135 AA; 15274 MW; 58B717453AA900BD CRC64;
MWMNFESLQI ARAYLFGEVK YLDLMLVLNI IDIITGVIKA WKFKELRSRS AWFGYVRKML
SFLVVIVANA IDTIMDLNGV LTFATVLFYI ANEGLSITEN LAQIGVKIPA VITDRLHVIE
SDNDQKTEKD DQAAG