ID   VLYS_BPPH1              Reviewed;         135 AA.
AC   Q9ZXD8;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Probable holin;
DE   AltName: Full=Lysis protein;
GN   Name=45;
OS   Bacillus phage phi105 (Bacteriophage phi-105).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Spizizenvirus; Bacillus virus phi105.
OX   NCBI_TaxID=10717;
OH   NCBI_TaxID=1423; Bacillus subtilis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kobayashi K., Okamura K., Inoue T., Sato T., Kobayashi Y.;
RT   "Complete nucleotide sequence of Bacillus subtilis phage phi-105.";
RL   Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Produces a lesion in the cytoplasmic membrane allowing the
CC       phage lysosyme to attack the peptidoglycan. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the bacteriophage holin family. Cp-1 holin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AB016282; BAA36651.1; -; Genomic_DNA.
DR   PIR; T13534; T13534.
DR   RefSeq; NP_690778.1; NC_004167.1.
DR   GeneID; 955202; -.
DR   KEGG; vg:955202; -.
DR   Proteomes; UP000008338; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   InterPro; IPR006480; Phage_holin_4_1.
DR   Pfam; PF05105; Phage_holin_4_1; 1.
DR   TIGRFAMs; TIGR01593; holin_tox_secr; 1.
PE   3: Inferred from homology;
KW   Cytolysis; Host cell lysis by virus; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix;
KW   Viral release from host cell.
FT   CHAIN           1..135
FT                   /note="Probable holin"
FT                   /id="PRO_0000172858"
FT   TRANSMEM        24..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   135 AA;  15274 MW;  58B717453AA900BD CRC64;
     MWMNFESLQI ARAYLFGEVK YLDLMLVLNI IDIITGVIKA WKFKELRSRS AWFGYVRKML
     SFLVVIVANA IDTIMDLNGV LTFATVLFYI ANEGLSITEN LAQIGVKIPA VITDRLHVIE
     SDNDQKTEKD DQAAG