ID   CALD_PENDC              Reviewed;         494 AA.
AC   A0A1V6P9U2;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Transcriptional regulator calD {ECO:0000303|PubMed:30598828};
DE   AltName: Full=Calbistrin biosynthesis cluster protein D {ECO:0000303|PubMed:30598828};
GN   Name=calD {ECO:0000303|PubMed:30598828}; ORFNames=PENDEC_c013G04601;
OS   Penicillium decumbens.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=69771;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 11843;
RX   PubMed=28368369; DOI=10.1038/nmicrobiol.2017.44;
RA   Nielsen J.C., Grijseels S., Prigent S., Ji B., Dainat J., Nielsen K.F.,
RA   Frisvad J.C., Workman M., Nielsen J.;
RT   "Global analysis of biosynthetic gene clusters reveals vast potential of
RT   secondary metabolite production in Penicillium species.";
RL   Nat. Microbiol. 2:17044-17044(2017).
RN   [2]
RP   BIOTECHNOLOGY.
RX   PubMed=8436557; DOI=10.7164/antibiotics.46.34;
RA   Jackson M., Karwowski J.P., Humphrey P.E., Kohl W.L., Barlow G.J.,
RA   Tanaka S.K.;
RT   "Calbistrins, novel antifungal agents produced by Penicillium restrictum.
RT   I. Production, taxonomy of the producing organism and biological
RT   activity.";
RL   J. Antibiot. 46:34-38(1993).
RN   [3]
RP   BIOTECHNOLOGY.
RX   PubMed=24287995; DOI=10.3390/molecules181214629;
RA   Bladt T.T., Duerr C., Knudsen P.B., Kildgaard S., Frisvad J.C.,
RA   Gotfredsen C.H., Seiffert M., Larsen T.O.;
RT   "Bio-activity and dereplication-based discovery of ophiobolins and other
RT   fungal secondary metabolites targeting leukemia cells.";
RL   Molecules 18:14629-14650(2013).
RN   [4]
RP   IDENTIFICATION, AND INDUCTION.
RX   PubMed=30598828; DOI=10.1186/s40694-018-0063-4;
RA   Grijseels S., Pohl C., Nielsen J.C., Wasil Z., Nygaard Y., Nielsen J.,
RA   Frisvad J.C., Nielsen K.F., Workman M., Larsen T.O., Driessen A.J.M.,
RA   Frandsen R.J.N.;
RT   "Identification of the decumbenone biosynthetic gene cluster in Penicillium
RT   decumbens and the importance for production of calbistrin.";
RL   Fungal Biol. Biotechnol. 5:18-18(2018).
CC   -!- FUNCTION: Transcription co-regulator that might be involved in the
CC       regulation of the expression of the gene cluster that mediates the
CC       biosynthesis of calbistrins and related compounds such as decumbenones.
CC       Calbistrin A is a secondary metabolite with an interesting structure
CC       that was recently found to have bioactivity against leukemia cells. It
CC       consists of two polyketides linked by an ester bond: a bicyclic decalin
CC       containing polyketide and a linear 12 carbon dioic acid structure.
CC       {ECO:0000250|UniProtKB:A0A1B4XBK2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression is induced in complex medium (Czapek yeast
CC       autolysate medium) supporting calbistrin production.
CC       {ECO:0000269|PubMed:30598828}.
CC   -!- BIOTECHNOLOGY: Calbistrin A has been reported to possess a number of
CC       interesting bioactivities including antifungal active against Candida
CC       albicans and cytotoxic toward both healthy and leukemic human cells.
CC       {ECO:0000269|PubMed:24287995, ECO:0000269|PubMed:8436557}.
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DR   EMBL; MDYL01000013; OQD73799.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V6P9U2; -.
DR   SMR; A0A1V6P9U2; -.
DR   OMA; TIIFRTF; -.
DR   OrthoDB; 643224at2759; -.
DR   Proteomes; UP000191522; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.30.559.10; -; 2.
DR   InterPro; IPR023213; CAT-like_dom_sf.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..494
FT                   /note="Transcriptional regulator calD"
FT                   /id="PRO_0000446489"
SQ   SEQUENCE   494 AA;  56129 MW;  EA313C4712FFA708 CRC64;
     MFGLFRSKAP EAPPKHPTDT IIPLNAADDT EVLRSVVVVL SYRFDDVLDP VKLKSSFEKL
     LDRPGWRKIG ARLRLNDNGR LEYHIPERYD EKRPIVTWSH VSHNVSVLKH PLSSKLPRAS
     ARPAVVGDPN DFDELTSSPE APKTLHDYLT RDVPQLCLHV VSFTDSTLVS ISLPHTLTDG
     TGGAQIYRCW ALVLQDRDDE VPPFHGYDSD PLATFGETSS QPYMYDPKLL TGWRKWLFIL
     YQVYDGWRYR TSSRIVCVPG PYLAAQRKKA IEEIRAETGN DKAFVSDNDV LTAWFTRLAV
     GHYPRNSNLT VRIMNAFALA SVLGNDRLPS TKAFISNAAT EIYTFLSVRD FFTKPLSYAA
     YAIRRSMMEG GTREQVEALQ AVKKQTLARE GHTWPIFGDA SMEMMSYSNW TKGKYFETDF
     SAAIVKEGFA REARAEKPGF ASMVQFNAWS TKFDLRNLMP IMGKDAAGNY WLQGPLRDVV
     WKRIEKELRE EPLQ