ID   VM1_CROMN               Reviewed;          12 AA.
AC   Q7LZJ1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Snake venom metalloproteinase;
DE            Short=SVMP;
DE            EC=3.4.24.-;
DE   AltName: Full=Proteinase E;
DE   Flags: Fragment;
OS   Crotalus molossus nigrescens (Black-tailed rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=8734;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=2188398; DOI=10.1016/0041-0101(90)90064-e;
RA   Ramirez G.A., Fletcher P.L. Jr., Possani L.D.;
RT   "Characterization of the venom from Crotalus molossus nigrescens Gloyd
RT   (black tail rattlesnake): isolation of two proteases.";
RL   Toxicon 28:285-297(1990).
CC   -!- FUNCTION: Snake venom metalloproteinase that impairs hemostasis in the
CC       envenomed animal. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000250}.
CC   -!- MISCELLANEOUS: The molecular weight was determined to be 21,390 Da.
CC   -!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family. P-I
CC       subfamily. {ECO:0000305}.
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DR   PIR; A34858; A34858.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Disulfide bond;
KW   Hemostasis impairing toxin; Hydrolase; Metal-binding; Metalloprotease;
KW   Protease; Secreted; Toxin; Zinc.
FT   CHAIN           <1..>12
FT                   /note="Snake venom metalloproteinase"
FT                   /id="PRO_0000408032"
FT   DOMAIN          4..>12
FT                   /note="Peptidase M12B"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00276"
FT   BINDING         7
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000250"
FT   UNSURE          7
FT                   /note="E or Q"
FT   NON_TER         1
FT   NON_TER         12
SQ   SEQUENCE   12 AA;  1408 MW;  07003711192B02DB CRC64;
     FAKRYVELVI VA