VM2I1_GLOUS
ID VM2I1_GLOUS Reviewed; 71 AA.
AC Q7LZI5;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Disintegrin ussuristatin-1;
DE Short=US-1;
OS Gloydius ussuriensis (Ussuri mamushi) (Gloydius blomhoffii ussuriensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
OX NCBI_TaxID=35671 {ECO:0000312|PIR:A59413};
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, AND SUBUNIT.
RC TISSUE=Venom {ECO:0000269|PubMed:9880793};
RX PubMed=9880793; DOI=10.1093/oxfordjournals.jbchem.a022264;
RA Oshikawa K., Terada S.;
RT "Ussuristatin 2, a novel KGD-bearing disintegrin from Agkistrodon
RT ussuriensis venom.";
RL J. Biochem. 125:31-35(1999).
CC -!- FUNCTION: Strongly suppress platelet aggregation induced by ADP,
CC collagen, thrombin, and epinephrine (IC(50)=17-33 nM). Also dose-
CC dependently inhibits the adhesion of human melanoma cells to fibrinogen
CC and fibronectin. {ECO:0000269|PubMed:9880793}.
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:9880793}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MISCELLANEOUS: The disintegrin belongs to the medium disintegrin
CC subfamily.
CC -!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family. P-II
CC subfamily. P-IIa sub-subfamily. {ECO:0000305}.
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DR PIR; A59413; A59413.
DR AlphaFoldDB; Q7LZI5; -.
DR SMR; Q7LZI5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 4.10.70.10; -; 1.
DR InterPro; IPR018358; Disintegrin_CS.
DR InterPro; IPR001762; Disintegrin_dom.
DR InterPro; IPR036436; Disintegrin_dom_sf.
DR Pfam; PF00200; Disintegrin; 1.
DR PRINTS; PR00289; DISINTEGRIN.
DR SMART; SM00050; DISIN; 1.
DR SUPFAM; SSF57552; SSF57552; 1.
DR PROSITE; PS00427; DISINTEGRIN_1; 1.
DR PROSITE; PS50214; DISINTEGRIN_2; 1.
PE 1: Evidence at protein level;
KW Cell adhesion impairing toxin; Direct protein sequencing; Disulfide bond;
KW Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW Secreted; Toxin.
FT CHAIN 1..71
FT /note="Disintegrin ussuristatin-1"
FT /id="PRO_0000101780"
FT DOMAIN 1..71
FT /note="Disintegrin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT MOTIF 49..51
FT /note="Cell attachment site"
FT DISULFID 4..13
FT /evidence="ECO:0000250|UniProtKB:P22828,
FT ECO:0000255|PROSITE-ProRule:PRU00068"
FT DISULFID 6..14
FT /evidence="ECO:0000250|UniProtKB:P22828,
FT ECO:0000255|PROSITE-ProRule:PRU00068"
FT DISULFID 19..33
FT /evidence="ECO:0000250|UniProtKB:P22828,
FT ECO:0000255|PROSITE-ProRule:PRU00068"
FT DISULFID 27..57
FT /evidence="ECO:0000250|UniProtKB:P22828,
FT ECO:0000255|PROSITE-ProRule:PRU00068"
FT DISULFID 32..36
FT /evidence="ECO:0000250|UniProtKB:P22828,
FT ECO:0000255|PROSITE-ProRule:PRU00068"
FT DISULFID 45..64
FT /evidence="ECO:0000250|UniProtKB:P22828,
FT ECO:0000255|PROSITE-ProRule:PRU00068"
SQ SEQUENCE 71 AA; 7470 MW; 46CEAF6E272574D4 CRC64;
GEECDCGSPG NPCCDAATCK LRPGAQCAEG LCCEQCRFIK AGTVCRVARG DWNDDKCTGQ
SADCPRNGFY G
