ID   CALI_BOVIN              Reviewed;         588 AA.
AC   Q28068; Q2T9L7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Calicin;
GN   Name=CCIN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Sperm;
RX   PubMed=7641791; DOI=10.1006/excr.1995.1246;
RA   von Buelow M., Heid H.W., Hess H., Franke W.W.;
RT   "Molecular nature of calicin, a major basic protein of the mammalian sperm
RT   head cytoskeleton.";
RL   Exp. Cell Res. 219:407-413(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible morphogenic cytoskeletal element in spermiogenic
CC       differentiation.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca,
CC       calyx. Note=Sperm head cytoskeletal structure tightly associated to the
CC       nucleus.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z46968; CAA87089.1; -; mRNA.
DR   EMBL; BC111363; AAI11364.1; -; mRNA.
DR   PIR; I46003; I46003.
DR   RefSeq; NP_776430.2; NM_174005.4.
DR   RefSeq; XP_010806216.1; XM_010807914.2.
DR   AlphaFoldDB; Q28068; -.
DR   SMR; Q28068; -.
DR   STRING; 9913.ENSBTAP00000028915; -.
DR   PaxDb; Q28068; -.
DR   PRIDE; Q28068; -.
DR   Ensembl; ENSBTAT00000028915; ENSBTAP00000028915; ENSBTAG00000021696.
DR   GeneID; 281041; -.
DR   KEGG; bta:281041; -.
DR   CTD; 881; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021696; -.
DR   VGNC; VGNC:26939; CCIN.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000162268; -.
DR   HOGENOM; CLU_466589_0_0_1; -.
DR   InParanoid; Q28068; -.
DR   OMA; MPYKAAA; -.
DR   OrthoDB; 311575at2759; -.
DR   TreeFam; TF331981; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000021696; Expressed in spermatid and 17 other tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IDA:MGI.
DR   GO; GO:0032839; C:dendrite cytoplasm; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR017096; BTB-kelch_protein.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW   Direct protein sequencing; Kelch repeat; Phosphoprotein;
KW   Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..588
FT                   /note="Calicin"
FT                   /id="PRO_0000119066"
FT   DOMAIN          28..98
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REPEAT          280..327
FT                   /note="Kelch 1"
FT   REPEAT          328..375
FT                   /note="Kelch 2"
FT   REPEAT          377..423
FT                   /note="Kelch 3"
FT   REPEAT          425..475
FT                   /note="Kelch 4"
FT   REPEAT          476..525
FT                   /note="Kelch 5"
FT   REPEAT          526..580
FT                   /note="Kelch 6"
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5XI58"
FT   CONFLICT        367
FT                   /note="F -> I (in Ref. 2; AAI11364)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   588 AA;  66890 MW;  9C0A0CD1985A7F78 CRC64;
     MKLEFTEKNY NSFVLQNLNK QRKRKEYWDI ALTVDHHVFF AHRNVLAAVS PLVKNLISNH
     DMKTTDELFI TIDPNYLSPT TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRIHC
     NDFLIKSIRR ANCLRYLFLA ELFELKEVSD LAYSGIRDNF HYWASPEGCV HFMRCPPVIF
     GRLLRDENLH VLNEDQALNA LINWVCFRKD EREKYFKKFF NYINLNAVSN KTLMYASNKL
     MGMENSSAHS TLIESVLVDR KQERPTSLLS YQRKGALLDS VVILGGQKAH GKFNDGVFAY
     IIQENLWLKL SEMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD
     LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK ETWCLAGKMS IPMDGTAVIT
     RGDRNLYIVT GRCLVKGYIS RVGVVDCFDT NTGEVVQCIT FPIEFNHRPL LSFHQDNILC
     VYSHRQSVEI NLQKVKANKT TTSVPLLPNN CPLDVSHAIC SVGDNKVFVC GGVTTTTDVQ
     TKDYTINPNA YLLDQKAGEW KTLAPPPEAL DCPACCLAKL PCKILQRI