ID   VM2_BOTFO               Reviewed;          20 AA.
AC   P0DMH4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Disintegrin;
DE   AltName: Full=Platelet aggregation activation inhibitor;
DE   Flags: Fragment;
OS   Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=157549;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=18760386; DOI=10.1016/j.jprot.2008.07.007;
RA   Tashima A.K., Sanz L., Camargo A.C., Serrano S.M., Calvete J.J.;
RT   "Snake venomics of the Brazilian pitvipers Bothrops cotiara and Bothrops
RT   fonsecai. Identification of taxonomy markers.";
RL   J. Proteomics 71:473-485(2008).
CC   -!- FUNCTION: Inhibits fibrinogen interaction with platelets. Acts by
CC       binding to alpha-IIb/beta-3 (ITGA2B/ITGB3) on the platelet surface and
CC       inhibits aggregation induced by ADP, thrombin, platelet-activating
CC       factor and collagen (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: The disintegrin belongs to the medium disintegrin
CC       subfamily. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family. P-II
CC       subfamily. P-IIa sub-subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P0DMH4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Toxin.
FT   CHAIN           1..>20
FT                   /note="Disintegrin"
FT                   /id="PRO_0000428814"
FT   DOMAIN          1..>20
FT                   /note="Disintegrin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        6..15
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        8..16
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2015 MW;  785096AE7DD5A1BE CRC64;
     EAGEECDCGT PENPCCDAAT