CALI_MOUSE
ID CALI_MOUSE Reviewed; 588 AA.
AC Q8CDE2;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Calicin;
GN Name=Ccin;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Possible morphogenetic cytoskeletal element in spermiogenic
CC differentiation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx
CC {ECO:0000250}. Note=Sperm head cytoskeletal structure tightly
CC associated to the nucleus. {ECO:0000250}.
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DR EMBL; AK030197; BAC26835.1; -; mRNA.
DR EMBL; AL732563; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS18118.1; -.
DR RefSeq; NP_001002787.1; NM_001002787.2.
DR AlphaFoldDB; Q8CDE2; -.
DR SMR; Q8CDE2; -.
DR BioGRID; 243037; 1.
DR STRING; 10090.ENSMUSP00000092725; -.
DR iPTMnet; Q8CDE2; -.
DR PhosphoSitePlus; Q8CDE2; -.
DR PaxDb; Q8CDE2; -.
DR PRIDE; Q8CDE2; -.
DR ProteomicsDB; 265504; -.
DR Antibodypedia; 11871; 137 antibodies from 22 providers.
DR DNASU; 442829; -.
DR Ensembl; ENSMUST00000095107; ENSMUSP00000092725; ENSMUSG00000070999.
DR GeneID; 442829; -.
DR KEGG; mmu:442829; -.
DR UCSC; uc008srg.1; mouse.
DR CTD; 881; -.
DR MGI; MGI:3045316; Ccin.
DR VEuPathDB; HostDB:ENSMUSG00000070999; -.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000162268; -.
DR HOGENOM; CLU_466589_0_0_1; -.
DR InParanoid; Q8CDE2; -.
DR OMA; MPYKAAA; -.
DR OrthoDB; 311575at2759; -.
DR PhylomeDB; Q8CDE2; -.
DR TreeFam; TF331981; -.
DR BioGRID-ORCS; 442829; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8CDE2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q8CDE2; protein.
DR Bgee; ENSMUSG00000070999; Expressed in seminiferous tubule of testis and 5 other tissues.
DR ExpressionAtlas; Q8CDE2; baseline and differential.
DR Genevisible; Q8CDE2; MM.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; ISO:MGI.
DR GO; GO:0032839; C:dendrite cytoplasm; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 2.120.10.80; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 3.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW Kelch repeat; Phosphoprotein; Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1..588
FT /note="Calicin"
FT /id="PRO_0000284432"
FT DOMAIN 28..98
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 133..235
FT /note="BACK"
FT REPEAT 280..327
FT /note="Kelch 1"
FT REPEAT 328..375
FT /note="Kelch 2"
FT REPEAT 377..423
FT /note="Kelch 3"
FT REPEAT 425..475
FT /note="Kelch 4"
FT REPEAT 476..525
FT /note="Kelch 5"
FT REPEAT 526..580
FT /note="Kelch 6"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5XI58"
SQ SEQUENCE 588 AA; 66750 MW; 088F8F663B8A2E0F CRC64;
MKLEFTEKNY NSFVLQNLNK QRKRKEYWDM ALTVDHHVFF AHRNVLAAVS PLVKSLISSN
DMKTTDELYI TIDPNYLSPA TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRIHC
NDFLIKSIRR VNCLRYLFLA ELFELKEVSD LAYSGIRDNF HFWASPEGSM HFMRCPPVIF
GRLLRDENLH VLNEDQALSA LISWVYFRKE EREKYFKKFF NYINLNAVSN KTLMFASNKL
VGLENNSAHA TLIESVLMDR KQERPCSLLS YQRKGALLDS VVILGGQKAH GKFNDGVFAY
IIQENLWLKL SEMPYRAAAL SATAAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD
LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EAWCLAGKMS IPMDGTAVIT
KGDRNLYIVT GRCLVKGYIS RVGVVDCFDT CTGEVVQCIT FPIEFNHRPL LSFHQDNILR
VHSHRQSVEI NLQKIKANKS TTSVPLLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ
TKDYTINPNA YLLDQKIGEW QTLACPPEAL DCPACCLAKL PCKILQRI
