ID   VM2_CROMR               Reviewed;          37 AA.
AC   P0DW29;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   03-AUG-2022, sequence version 1.
DT   03-AUG-2022, entry version 1.
DE   RecName: Full=Disintegrin morulustatin {ECO:0000303|PubMed:28713196};
DE   Flags: Fragments;
OS   Crotalus morulus (Tamaulipan rock rattlesnake) (Crotalus lepidus morulus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=2782198;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=28713196;
RA   Borja M., Galan J.A., Cantu E. Jr., Zugasti-Cruz A., Rodriguez-Acosta A.,
RA   Lazcano D., Lucena S., Suntravat M., Sanchez Y.E.E.;
RT   "Morulustatin, a disintegrin that inhibits adp-induced platelet
RT   aggregation, isolated from the Mexican Tamaulipan rock rattlesnake
RT   (Crotalus lepidus morulus).";
RL   Rev. Cient. (Maracaibo) 26:86-94(2016).
CC   -!- FUNCTION: Inhibits ADP-induced platelet aggregation in human whole
CC       blood in a concentration-dependent manner (IC(50)=89.5 nM).
CC       {ECO:0000269|PubMed:28713196}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28713196}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:28713196}.
CC   -!- MISCELLANEOUS: The disintegrin belongs to the medium disintegrin
CC       subfamily.
CC   -!- SIMILARITY: Belongs to the venom metalloproteinase (M12B) family. P-II
CC       subfamily. P-IIa sub-subfamily. {ECO:0000305}.
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PE   1: Evidence at protein level;
KW   Cell adhesion impairing toxin; Direct protein sequencing; Disulfide bond;
KW   Hemostasis impairing toxin; Platelet aggregation inhibiting toxin;
KW   Secreted; Toxin.
FT   CHAIN           <1..>37
FT                   /note="Disintegrin morulustatin"
FT                   /id="PRO_0000456227"
FT   DISULFID        12..16
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        13..?
FT                   /evidence="ECO:0000305"
FT   DISULFID        22..36
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00068"
FT   DISULFID        24..31
FT                   /evidence="ECO:0000250|UniProtKB:P18619"
FT   NON_CONS        17..18
FT                   /evidence="ECO:0000305|PubMed:28713196"
FT   NON_TER         1
FT                   /evidence="ECO:0000305|PubMed:28713196"
FT   NON_TER         37
FT                   /evidence="ECO:0000305|PubMed:28713196"
SQ   SEQUENCE   37 AA;  3739 MW;  F7ABA64985FC6A98 CRC64;
     LRPGAQCADG LCCDQCRAGE ECDCGSPANC CDAATCK