ID   CALI_RAT                Reviewed;         588 AA.
AC   Q5XI58;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Calicin;
GN   Name=Ccin;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA   Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.;
RT   "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT   regulation of aquaporin-2 phosphorylation at two sites.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
CC   -!- FUNCTION: Possible morphogenetic cytoskeletal element in spermiogenic
CC       differentiation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx
CC       {ECO:0000250}. Note=Sperm head cytoskeletal structure tightly
CC       associated to the nucleus. {ECO:0000250}.
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DR   EMBL; BC083832; AAH83832.1; -; mRNA.
DR   RefSeq; NP_001005904.1; NM_001005904.1.
DR   AlphaFoldDB; Q5XI58; -.
DR   SMR; Q5XI58; -.
DR   STRING; 10116.ENSRNOP00000019887; -.
DR   iPTMnet; Q5XI58; -.
DR   PhosphoSitePlus; Q5XI58; -.
DR   PaxDb; Q5XI58; -.
DR   PRIDE; Q5XI58; -.
DR   Ensembl; ENSRNOT00000019887; ENSRNOP00000019887; ENSRNOG00000014831.
DR   GeneID; 298392; -.
DR   KEGG; rno:298392; -.
DR   UCSC; RGD:1359369; rat.
DR   CTD; 881; -.
DR   RGD; 1359369; Ccin.
DR   eggNOG; KOG4441; Eukaryota.
DR   GeneTree; ENSGT00940000162268; -.
DR   HOGENOM; CLU_466589_0_0_1; -.
DR   InParanoid; Q5XI58; -.
DR   OMA; MPYKAAA; -.
DR   OrthoDB; 311575at2759; -.
DR   PhylomeDB; Q5XI58; -.
DR   TreeFam; TF331981; -.
DR   PRO; PR:Q5XI58; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000014831; Expressed in testis.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0033150; C:cytoskeletal calyx; IEA:UniProtKB-SubCell.
DR   GO; GO:0032839; C:dendrite cytoplasm; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 2.120.10.80; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011705; BACK.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   InterPro; IPR006652; Kelch_1.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF07707; BACK; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF01344; Kelch_1; 1.
DR   SMART; SM00875; BACK; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00612; Kelch; 3.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Differentiation;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat; Spermatogenesis.
FT   CHAIN           1..588
FT                   /note="Calicin"
FT                   /id="PRO_0000284433"
FT   DOMAIN          28..98
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          133..235
FT                   /note="BACK"
FT   REPEAT          280..327
FT                   /note="Kelch 1"
FT   REPEAT          328..375
FT                   /note="Kelch 2"
FT   REPEAT          377..423
FT                   /note="Kelch 3"
FT   REPEAT          425..475
FT                   /note="Kelch 4"
FT   REPEAT          476..525
FT                   /note="Kelch 5"
FT   REPEAT          526..580
FT                   /note="Kelch 6"
FT   MOD_RES         149
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:16641100"
SQ   SEQUENCE   588 AA;  66765 MW;  EE00F1D2341BFE49 CRC64;
     MKLEFTEKNY NSFVLQNLNK QRKRKEYWDM ALTVDHHVFF AHRNVLAAVS PLVKSLVSSN
     DMKTTDELYI TIDPNYLSPA TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRIHC
     NDFLIKSIRR VNCLRYLFLA ELFELKEVSD LAYSGIRDNF HFWASPEGSM HFMRCPPVIF
     GRLLRDENLH VLNEDQALSA LINWVYFRKE EREKYFKKFF NYINLNAVSN KTLMFASNKL
     TGLENNSAHA TLIESVLMDR KQERPCSLLS YQRKGALLDS VVILGGQKAH GKFNDGVFAY
     IIQENLWLKL SEMPYRAAAL SATAAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD
     LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EAWCLAGKMS IPMDGTAVIT
     KGDRNLYIVT GRCLVKGYIS RVGVVDCFDT CTGEVVQCIT FPIEFNHRPL LSFHQDNILR
     VHSHRQSVEI NLQKIKANKS TTSVPLLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ
     TKDYTINPNA YLLDQKIGEW KTLACPPEAL DCPACCLAKL PCKILQRI