CALL4_MOUSE
ID CALL4_MOUSE Reviewed; 153 AA.
AC Q91WQ9; Q3UJ19; Q8C1Q0; Q8R1P1; Q8VD39;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Calmodulin-like protein 4;
DE AltName: Full=Calmodulin-related;
DE Short=CALM-Rel;
GN Name=Calml4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=BALB/c X DBA/2; TISSUE=Liver;
RX PubMed=11709547; DOI=10.1074/jbc.m100751200;
RA Min S.H., Simmen R.C.M., Alhonen L., Halmekytoe M., Porter C.W., Jaenne J.,
RA Simmen F.A.;
RT "Altered levels of growth-related and novel gene transcripts in
RT reproductive and other tissues of female mice overexpressing
RT spermidine/spermine N1-acetyltransferase (SSAT).";
RL J. Biol. Chem. 277:3647-3657(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q91WQ9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91WQ9-2; Sequence=VSP_030438;
CC Name=3;
CC IsoId=Q91WQ9-3; Sequence=VSP_030437;
CC -!- SIMILARITY: Belongs to the calmodulin family. {ECO:0000305}.
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DR EMBL; AY061807; AAL38053.1; -; mRNA.
DR EMBL; AK008039; BAC25195.1; -; mRNA.
DR EMBL; AK146656; BAE27336.1; -; mRNA.
DR EMBL; BC013541; AAH13541.2; -; mRNA.
DR EMBL; BC023475; AAH23475.1; -; mRNA.
DR CCDS; CCDS40664.1; -. [Q91WQ9-1]
DR RefSeq; NP_612177.1; NM_138304.2. [Q91WQ9-1]
DR RefSeq; XP_006511595.1; XM_006511532.1. [Q91WQ9-3]
DR AlphaFoldDB; Q91WQ9; -.
DR SMR; Q91WQ9; -.
DR STRING; 10090.ENSMUSP00000034777; -.
DR iPTMnet; Q91WQ9; -.
DR PhosphoSitePlus; Q91WQ9; -.
DR jPOST; Q91WQ9; -.
DR MaxQB; Q91WQ9; -.
DR PaxDb; Q91WQ9; -.
DR PeptideAtlas; Q91WQ9; -.
DR PRIDE; Q91WQ9; -.
DR ProteomicsDB; 265506; -. [Q91WQ9-1]
DR ProteomicsDB; 265507; -. [Q91WQ9-2]
DR ProteomicsDB; 265508; -. [Q91WQ9-3]
DR Antibodypedia; 42938; 133 antibodies from 22 providers.
DR DNASU; 75600; -.
DR Ensembl; ENSMUST00000034777; ENSMUSP00000034777; ENSMUSG00000032246. [Q91WQ9-1]
DR Ensembl; ENSMUST00000213643; ENSMUSP00000150355; ENSMUSG00000032246. [Q91WQ9-3]
DR Ensembl; ENSMUST00000215870; ENSMUSP00000148892; ENSMUSG00000032246. [Q91WQ9-2]
DR GeneID; 75600; -.
DR KEGG; mmu:75600; -.
DR UCSC; uc009qao.1; mouse. [Q91WQ9-2]
DR UCSC; uc009qap.1; mouse. [Q91WQ9-1]
DR CTD; 91860; -.
DR MGI; MGI:1922850; Calml4.
DR VEuPathDB; HostDB:ENSMUSG00000032246; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000157859; -.
DR HOGENOM; CLU_061288_2_0_1; -.
DR InParanoid; Q91WQ9; -.
DR OMA; FARSGHI; -.
DR OrthoDB; 1386217at2759; -.
DR PhylomeDB; Q91WQ9; -.
DR TreeFam; TF300912; -.
DR BioGRID-ORCS; 75600; 0 hits in 68 CRISPR screens.
DR ChiTaRS; Calml4; mouse.
DR PRO; PR:Q91WQ9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q91WQ9; protein.
DR Bgee; ENSMUSG00000032246; Expressed in choroid plexus epithelium and 189 other tissues.
DR ExpressionAtlas; Q91WQ9; baseline and differential.
DR Genevisible; Q91WQ9; MM.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..153
FT /note="Calmodulin-like protein 4"
FT /id="PRO_0000314934"
FT DOMAIN 8..43
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 44..79
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 81..116
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 117..152
FT /note="EF-hand 4"
FT /evidence="ECO:0000305"
FT VAR_SEQ 1..72
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030437"
FT VAR_SEQ 122..153
FT /note="VDDLFKEAGIEPNGQVKYDTFIQRITIPVRDY -> GTSLVGSERGNRGEGS
FT VL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030438"
FT CONFLICT 67
FT /note="S -> P (in Ref. 3; AAH23475)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 153 AA; 17671 MW; BDA67309D7F2082A CRC64;
MAKFLSQDQI NEYKECFSLY DKQQRGKIKA TDLLVSMRCL GASPTPGEVQ RHLQTHGIDK
NGELDFSTFL TIMHMQIKQE DPKKEILLAM LMADKEKKGY IMASELRSKL MKLGEKLTHK
EVDDLFKEAG IEPNGQVKYD TFIQRITIPV RDY
