ID   VMA21_BOVIN             Reviewed;         101 AA.
AC   A2VDK9;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Vacuolar ATPase assembly integral membrane protein VMA21 {ECO:0000255|HAMAP-Rule:MF_03058};
GN   Name=VMA21 {ECO:0000255|HAMAP-Rule:MF_03058};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of the V0 complex of the vacuolar
CC       ATPase (V-ATPase) in the endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:Q78T54}.
CC   -!- SUBUNIT: Associates with the V0 complex of the vacuolar ATPase (V-
CC       ATPase) (By similarity). Interacts with ATP6AP2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q3ZAQ7, ECO:0000255|HAMAP-Rule:MF_03058}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000255|HAMAP-Rule:MF_03058}; Multi-pass membrane protein
CC       {ECO:0000255|HAMAP-Rule:MF_03058}. Endoplasmic reticulum-Golgi
CC       intermediate compartment membrane {ECO:0000255|HAMAP-Rule:MF_03058};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}.
CC       Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000255|HAMAP-
CC       Rule:MF_03058}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_03058}.
CC   -!- SIMILARITY: Belongs to the VMA21 family. {ECO:0000255|HAMAP-
CC       Rule:MF_03058}.
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DR   EMBL; BC133287; AAI33288.1; -; mRNA.
DR   RefSeq; NP_001075085.1; NM_001081616.2.
DR   AlphaFoldDB; A2VDK9; -.
DR   SMR; A2VDK9; -.
DR   STRING; 9913.ENSBTAP00000008268; -.
DR   PaxDb; A2VDK9; -.
DR   PRIDE; A2VDK9; -.
DR   Ensembl; ENSBTAT00000008268; ENSBTAP00000008268; ENSBTAG00000006296.
DR   GeneID; 613674; -.
DR   KEGG; bta:613674; -.
DR   CTD; 203547; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006296; -.
DR   VGNC; VGNC:36804; VMA21.
DR   eggNOG; KOG4783; Eukaryota.
DR   GeneTree; ENSGT00390000017980; -.
DR   HOGENOM; CLU_143588_1_0_1; -.
DR   InParanoid; A2VDK9; -.
DR   OMA; PYFRGNE; -.
DR   OrthoDB; 1603333at2759; -.
DR   TreeFam; TF314021; -.
DR   Proteomes; UP000009136; Chromosome X.
DR   Bgee; ENSBTAG00000006296; Expressed in caput epididymis and 104 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   HAMAP; MF_03058; VMA21; 1.
DR   InterPro; IPR019013; Vma21.
DR   PANTHER; PTHR31792; PTHR31792; 1.
DR   Pfam; PF09446; VMA21; 1.
PE   3: Inferred from homology;
KW   Cytoplasmic vesicle; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..101
FT                   /note="Vacuolar ATPase assembly integral membrane protein
FT                   VMA21"
FT                   /id="PRO_0000331498"
FT   TOPO_DOM        1..25
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT   TOPO_DOM        47..65
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT   TOPO_DOM        87..101
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
SQ   SEQUENCE   101 AA;  11366 MW;  22C35B8920BE1F51 CRC64;
     MERLDKAALN ALQPSDFRNE SSLASTLKTL LFFTALMITV PIGLYFTTKS YVFEGAFGMS
     NRDSYFYAAI VAVVAVHVVL ALFVYVAWNE GSRQWREGKQ D