VMA21_CHICK
ID VMA21_CHICK Reviewed; 102 AA.
AC Q5ZLL0;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Vacuolar ATPase assembly integral membrane protein VMA21 {ECO:0000255|HAMAP-Rule:MF_03058};
GN Name=VMA21 {ECO:0000255|HAMAP-Rule:MF_03058}; ORFNames=RCJMB04_5k12;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Required for the assembly of the V0 complex of the vacuolar
CC ATPase (V-ATPase) in the endoplasmic reticulum.
CC {ECO:0000250|UniProtKB:Q78T54}.
CC -!- SUBUNIT: Associates with the V0 complex of the vacuolar ATPase (V-
CC ATPase) (By similarity). Interacts with ATP6AP2 (By similarity).
CC {ECO:0000250|UniProtKB:Q3ZAQ7}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000255|HAMAP-Rule:MF_03058}; Multi-pass membrane protein
CC {ECO:0000255|HAMAP-Rule:MF_03058}. Endoplasmic reticulum-Golgi
CC intermediate compartment membrane {ECO:0000255|HAMAP-Rule:MF_03058};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03058}.
CC Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000255|HAMAP-
CC Rule:MF_03058}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_03058}.
CC -!- SIMILARITY: Belongs to the VMA21 family. {ECO:0000255|HAMAP-
CC Rule:MF_03058}.
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DR EMBL; AJ719724; CAG31383.1; -; mRNA.
DR RefSeq; NP_001026298.1; NM_001031127.1.
DR AlphaFoldDB; Q5ZLL0; -.
DR SMR; Q5ZLL0; -.
DR STRING; 9031.ENSGALP00000014737; -.
DR PaxDb; Q5ZLL0; -.
DR GeneID; 422385; -.
DR KEGG; gga:422385; -.
DR CTD; 203547; -.
DR VEuPathDB; HostDB:geneid_422385; -.
DR eggNOG; KOG4783; Eukaryota.
DR InParanoid; Q5ZLL0; -.
DR OrthoDB; 1603333at2759; -.
DR PhylomeDB; Q5ZLL0; -.
DR PRO; PR:Q5ZLL0; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR HAMAP; MF_03058; VMA21; 1.
DR InterPro; IPR019013; Vma21.
DR PANTHER; PTHR31792; PTHR31792; 1.
DR Pfam; PF09446; VMA21; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..102
FT /note="Vacuolar ATPase assembly integral membrane protein
FT VMA21"
FT /id="PRO_0000331502"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT TOPO_DOM 52..66
FT /note="Lumenal"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
FT TOPO_DOM 88..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03058"
SQ SEQUENCE 102 AA; 11578 MW; CA060B651B3E1860 CRC64;
MERYDKATLN AAFAPEFRQN EGSLTSTLRT LLFFTALMIT LPVGLYFSSK AYIFEGTLGM
SNRDSYFYAA IVAVVTVHVV LAMFVYVAWS EGTRQWREGK QD
