CALL6_HUMAN
ID CALL6_HUMAN Reviewed; 181 AA.
AC Q8TD86; A2A2M3; Q6Q2C4;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Calmodulin-like protein 6;
DE AltName: Full=Calglandulin-like protein;
GN Name=CALML6; Synonyms=CAGLP, CALGP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Skeletal muscle;
RX PubMed=15621662; DOI=10.1080/10425170400012933;
RA Chen S., Guo J.-H., Saiyin H., Chen L., Zhou G.-J., Huang C.-Q., Yu L.;
RT "Cloning and characterization of human CAGLP gene encoding a novel EF-hand
RT protein.";
RL DNA Seq. 15:365-368(2004).
RN [2]
RP SEQUENCE REVISION.
RA Guo J.-H., Yu L.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- INTERACTION:
CC Q8TD86; P48539: PCP4; NbExp=3; IntAct=EBI-12041267, EBI-4287270;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15621662}. Nucleus
CC {ECO:0000269|PubMed:15621662}.
CC -!- TISSUE SPECIFICITY: Expressed in prostate, thymus, heart, skeleton
CC muscle, bone marrow and ovary. {ECO:0000269|PubMed:15621662}.
CC -!- SIMILARITY: Belongs to the calmodulin family. Calglandulin subfamily.
CC {ECO:0000305}.
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DR EMBL; AY566229; AAS67001.1; -; mRNA.
DR EMBL; AF490905; AAM08411.2; -; mRNA.
DR EMBL; AL109917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30566.1; -.
DR RefSeq; NP_619650.2; NM_138705.3.
DR AlphaFoldDB; Q8TD86; -.
DR SMR; Q8TD86; -.
DR BioGRID; 127872; 6.
DR IntAct; Q8TD86; 1.
DR STRING; 9606.ENSP00000304643; -.
DR iPTMnet; Q8TD86; -.
DR PhosphoSitePlus; Q8TD86; -.
DR BioMuta; CALML6; -.
DR DMDM; 74762617; -.
DR PaxDb; Q8TD86; -.
DR PeptideAtlas; Q8TD86; -.
DR PRIDE; Q8TD86; -.
DR Antibodypedia; 1629; 108 antibodies from 23 providers.
DR DNASU; 163688; -.
DR Ensembl; ENST00000307786.8; ENSP00000304643.3; ENSG00000169885.10.
DR GeneID; 163688; -.
DR KEGG; hsa:163688; -.
DR MANE-Select; ENST00000307786.8; ENSP00000304643.3; NM_138705.4; NP_619650.2.
DR UCSC; uc001aih.1; human.
DR CTD; 163688; -.
DR DisGeNET; 163688; -.
DR GeneCards; CALML6; -.
DR HGNC; HGNC:24193; CALML6.
DR HPA; ENSG00000169885; Group enriched (skeletal muscle, tongue).
DR MIM; 610171; gene.
DR neXtProt; NX_Q8TD86; -.
DR OpenTargets; ENSG00000169885; -.
DR PharmGKB; PA134968051; -.
DR VEuPathDB; HostDB:ENSG00000169885; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00940000163135; -.
DR InParanoid; Q8TD86; -.
DR OMA; NKGTFNC; -.
DR OrthoDB; 1470794at2759; -.
DR PhylomeDB; Q8TD86; -.
DR TreeFam; TF354258; -.
DR PathwayCommons; Q8TD86; -.
DR SignaLink; Q8TD86; -.
DR BioGRID-ORCS; 163688; 24 hits in 1067 CRISPR screens.
DR GenomeRNAi; 163688; -.
DR Pharos; Q8TD86; Tbio.
DR PRO; PR:Q8TD86; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q8TD86; protein.
DR Bgee; ENSG00000169885; Expressed in hindlimb stylopod muscle and 93 other tissues.
DR ExpressionAtlas; Q8TD86; baseline and differential.
DR Genevisible; Q8TD86; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0030234; F:enzyme regulator activity; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 4.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 4.
PE 1: Evidence at protein level;
KW Calcium; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..181
FT /note="Calmodulin-like protein 6"
FT /id="PRO_0000073548"
FT DOMAIN 33..68
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 69..104
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 107..142
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 143..178
FT /note="EF-hand 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 156
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 158
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 160
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 162
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 167
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VARIANT 60
FT /note="W -> R (in dbSNP:rs28581776)"
FT /id="VAR_048588"
SQ SEQUENCE 181 AA; 20690 MW; F29C088AFC42BB13 CRC64;
MGLQQEISLQ PWCHHPAESC QTTTDMTERL SAEQIKEYKG VFEMFDEEGN GEVKTGELEW
LMSLLGINPT KSELASMAKD VDRDNKGFFN CDGFLALMGV YHEKAQNQES ELRAAFRVFD
KEGKGYIDWN TLKYVLMNAG EPLNEVEAEQ MMKEADKDGD RTIDYEEFVA MMTGESFKLI
Q
