VMA5A_MOUSE
ID VMA5A_MOUSE Reviewed; 793 AA.
AC Q99KC8; Q3TTU2; Q3UVU1; Q3V3F2; Q6UN22; Q8BHA8; Q9CTV9;
DT 19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=von Willebrand factor A domain-containing protein 5A;
DE AltName: Full=Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog;
GN Name=Vwa5a; Synonyms=Loh11cr2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=14504409; DOI=10.1073/pnas.1934602100;
RA Martin E.S., Cesari R., Pentimalli F., Yoder K., Fishel R.,
RA Himelstein A.L., Martin S.E., Godwin A.K., Negrini M., Croce C.M.;
RT "The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor
RT gene.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:11517-11522(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Diencephalon, Eye, Head, Ovary, Pituitary, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-622, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Mast cell;
RX PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
RA Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA Kawakami T., Salomon A.R.;
RT "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT signaling.";
RL J. Immunol. 179:5864-5876(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in tumorigenesis as a tumor suppressor.
CC Altered expression of this protein and disruption of the molecular
CC pathway it is involved in may contribute directly to or modify
CC tumorigenesis (By similarity). {ECO:0000250}.
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DR EMBL; AY366502; AAQ94870.1; -; mRNA.
DR EMBL; AK019914; BAB31913.3; -; mRNA.
DR EMBL; AK041397; BAE20590.1; -; mRNA.
DR EMBL; AK053665; BAC35467.1; -; mRNA.
DR EMBL; AK054497; BAC35804.1; -; mRNA.
DR EMBL; AK136934; BAE23178.1; -; mRNA.
DR EMBL; AK161193; BAE36232.1; -; mRNA.
DR EMBL; BC004727; AAH04727.1; -; mRNA.
DR EMBL; BC065153; AAH65153.1; -; mRNA.
DR CCDS; CCDS23024.1; -.
DR RefSeq; NP_001139429.1; NM_001145957.1.
DR RefSeq; NP_766355.3; NM_172767.3.
DR AlphaFoldDB; Q99KC8; -.
DR SMR; Q99KC8; -.
DR BioGRID; 212436; 5.
DR STRING; 10090.ENSMUSP00000001544; -.
DR iPTMnet; Q99KC8; -.
DR PhosphoSitePlus; Q99KC8; -.
DR SwissPalm; Q99KC8; -.
DR EPD; Q99KC8; -.
DR jPOST; Q99KC8; -.
DR MaxQB; Q99KC8; -.
DR PaxDb; Q99KC8; -.
DR PeptideAtlas; Q99KC8; -.
DR PRIDE; Q99KC8; -.
DR ProteomicsDB; 297606; -.
DR DNASU; 67776; -.
DR Ensembl; ENSMUST00000001544; ENSMUSP00000001544; ENSMUSG00000023186.
DR Ensembl; ENSMUST00000118144; ENSMUSP00000113596; ENSMUSG00000023186.
DR GeneID; 67776; -.
DR KEGG; mmu:67776; -.
DR UCSC; uc009oxa.2; mouse.
DR CTD; 4013; -.
DR MGI; MGI:1915026; Vwa5a.
DR VEuPathDB; HostDB:ENSMUSG00000023186; -.
DR eggNOG; ENOG502QRPK; Eukaryota.
DR GeneTree; ENSGT00940000159961; -.
DR HOGENOM; CLU_003826_4_0_1; -.
DR InParanoid; Q99KC8; -.
DR OMA; FNVIRFD; -.
DR OrthoDB; 955432at2759; -.
DR PhylomeDB; Q99KC8; -.
DR TreeFam; TF329720; -.
DR BioGRID-ORCS; 67776; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Vwa5a; mouse.
DR PRO; PR:Q99KC8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q99KC8; protein.
DR Bgee; ENSMUSG00000023186; Expressed in stroma of bone marrow and 233 other tissues.
DR ExpressionAtlas; Q99KC8; baseline and differential.
DR Genevisible; Q99KC8; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR013694; VIT.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF08487; VIT; 1.
DR Pfam; PF13768; VWA_3; 1.
DR SMART; SM00609; VIT; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR PROSITE; PS51468; VIT; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Tumor suppressor.
FT CHAIN 1..793
FT /note="von Willebrand factor A domain-containing protein
FT 5A"
FT /id="PRO_0000084412"
FT DOMAIN 1..131
FT /note="VIT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT DOMAIN 281..469
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT MOD_RES 622
FT /note="Phosphotyrosine"
FT /evidence="ECO:0007744|PubMed:17947660"
FT CONFLICT 152
FT /note="R -> G (in Ref. 2; BAB31913)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="P -> T (in Ref. 2; BAE23178)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="T -> I (in Ref. 1; AAQ94870)"
FT /evidence="ECO:0000305"
FT CONFLICT 347
FT /note="Q -> R (in Ref. 2; BAE20590)"
FT /evidence="ECO:0000305"
FT CONFLICT 733
FT /note="S -> A (in Ref. 3; AAH04727)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 793 AA; 87143 MW; 3A9FD99F03C600AC CRC64;
MEHHCGLITS NKETVPLKNI SVTLSINEFV AAVVATLNYE NEEKVPLEAT FVFPMDEDSA
VYSFEALVDG KKIVAELQDK MKAHSEYEEA LSQGHQAYLL EEDDYSRDVF SCNVGNLQPG
AKVAVTLRYV QELPLETDGA LRYLLPAILN PRYQLSEQSA NSCLNIQKPT VPLEDLPYTL
NMTATITSQH GIERVQSNCS LSPIQYLTDD KTSAQVSLTE GHKFDRDVEL LIYYNEVHSP
SVAVEMGMLD MKPDSLMGAP SAMVSFYPDI PEVEASKACG EFVFLMDRSG SMDSPMSTEN
NSQLRIEAAK ETLLLLLKSL PMGCYFNIYG FGSSYEKFFP ESVKYTQDTM EDAVKRVKAL
KANLGGTEIL TPLCNIYKAS SIPGHPLQLF VFTDGEVSDT FSVIREVKLN SKKHRCFSFG
IGQGASTSLI KNIARVSGGT AVFITGKDRM QTKALGSLKF ALQCAVDNIS LSWDLPPGLS
VKMLSPEQLT IFRGQRLIIY AQLTGLMPQV ESTGAVCLKH ILQGRSLENR VTFSLQPKAN
DNFTIHRLAA KSLIQTKDFG SQEASKEEKE DVMNISLQSG VLSSFTAFIA INKELNKPVQ
GPLAHRVIPR PVMAGSSSMR FYSSFSGGFK GPQPRSLRVP AYDLCSAESA NLVLKKSACS
AIQKKKTNSS TNKSNLKKEH KAFGENAVVQ LISLQKANGS WELDEDLTKI LGTKSKDIKA
ANPAKHEDPS AWSTVLAVVW LHANGTDLKC EWELLERKAV AWLHDHAGSS IPMLVQAANS
LLKLSVNPAV FGV
