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VMA5A_MOUSE
ID   VMA5A_MOUSE             Reviewed;         793 AA.
AC   Q99KC8; Q3TTU2; Q3UVU1; Q3V3F2; Q6UN22; Q8BHA8; Q9CTV9;
DT   19-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=von Willebrand factor A domain-containing protein 5A;
DE   AltName: Full=Loss of heterozygosity 11 chromosomal region 2 gene A protein homolog;
GN   Name=Vwa5a; Synonyms=Loh11cr2a;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14504409; DOI=10.1073/pnas.1934602100;
RA   Martin E.S., Cesari R., Pentimalli F., Yoder K., Fishel R.,
RA   Himelstein A.L., Martin S.E., Godwin A.K., Negrini M., Croce C.M.;
RT   "The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor
RT   gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:11517-11522(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RC   TISSUE=Diencephalon, Eye, Head, Ovary, Pituitary, and Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-622, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Mast cell;
RX   PubMed=17947660; DOI=10.4049/jimmunol.179.9.5864;
RA   Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,
RA   Kawakami T., Salomon A.R.;
RT   "Quantitative time-resolved phosphoproteomic analysis of mast cell
RT   signaling.";
RL   J. Immunol. 179:5864-5876(2007).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC   Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May play a role in tumorigenesis as a tumor suppressor.
CC       Altered expression of this protein and disruption of the molecular
CC       pathway it is involved in may contribute directly to or modify
CC       tumorigenesis (By similarity). {ECO:0000250}.
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DR   EMBL; AY366502; AAQ94870.1; -; mRNA.
DR   EMBL; AK019914; BAB31913.3; -; mRNA.
DR   EMBL; AK041397; BAE20590.1; -; mRNA.
DR   EMBL; AK053665; BAC35467.1; -; mRNA.
DR   EMBL; AK054497; BAC35804.1; -; mRNA.
DR   EMBL; AK136934; BAE23178.1; -; mRNA.
DR   EMBL; AK161193; BAE36232.1; -; mRNA.
DR   EMBL; BC004727; AAH04727.1; -; mRNA.
DR   EMBL; BC065153; AAH65153.1; -; mRNA.
DR   CCDS; CCDS23024.1; -.
DR   RefSeq; NP_001139429.1; NM_001145957.1.
DR   RefSeq; NP_766355.3; NM_172767.3.
DR   AlphaFoldDB; Q99KC8; -.
DR   SMR; Q99KC8; -.
DR   BioGRID; 212436; 5.
DR   STRING; 10090.ENSMUSP00000001544; -.
DR   iPTMnet; Q99KC8; -.
DR   PhosphoSitePlus; Q99KC8; -.
DR   SwissPalm; Q99KC8; -.
DR   EPD; Q99KC8; -.
DR   jPOST; Q99KC8; -.
DR   MaxQB; Q99KC8; -.
DR   PaxDb; Q99KC8; -.
DR   PeptideAtlas; Q99KC8; -.
DR   PRIDE; Q99KC8; -.
DR   ProteomicsDB; 297606; -.
DR   DNASU; 67776; -.
DR   Ensembl; ENSMUST00000001544; ENSMUSP00000001544; ENSMUSG00000023186.
DR   Ensembl; ENSMUST00000118144; ENSMUSP00000113596; ENSMUSG00000023186.
DR   GeneID; 67776; -.
DR   KEGG; mmu:67776; -.
DR   UCSC; uc009oxa.2; mouse.
DR   CTD; 4013; -.
DR   MGI; MGI:1915026; Vwa5a.
DR   VEuPathDB; HostDB:ENSMUSG00000023186; -.
DR   eggNOG; ENOG502QRPK; Eukaryota.
DR   GeneTree; ENSGT00940000159961; -.
DR   HOGENOM; CLU_003826_4_0_1; -.
DR   InParanoid; Q99KC8; -.
DR   OMA; FNVIRFD; -.
DR   OrthoDB; 955432at2759; -.
DR   PhylomeDB; Q99KC8; -.
DR   TreeFam; TF329720; -.
DR   BioGRID-ORCS; 67776; 4 hits in 71 CRISPR screens.
DR   ChiTaRS; Vwa5a; mouse.
DR   PRO; PR:Q99KC8; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   RNAct; Q99KC8; protein.
DR   Bgee; ENSMUSG00000023186; Expressed in stroma of bone marrow and 233 other tissues.
DR   ExpressionAtlas; Q99KC8; baseline and differential.
DR   Genevisible; Q99KC8; MM.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF13768; VWA_3; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome; Tumor suppressor.
FT   CHAIN           1..793
FT                   /note="von Willebrand factor A domain-containing protein
FT                   5A"
FT                   /id="PRO_0000084412"
FT   DOMAIN          1..131
FT                   /note="VIT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00801"
FT   DOMAIN          281..469
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   MOD_RES         622
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0007744|PubMed:17947660"
FT   CONFLICT        152
FT                   /note="R -> G (in Ref. 2; BAB31913)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        172
FT                   /note="P -> T (in Ref. 2; BAE23178)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="T -> I (in Ref. 1; AAQ94870)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        347
FT                   /note="Q -> R (in Ref. 2; BAE20590)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        733
FT                   /note="S -> A (in Ref. 3; AAH04727)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   793 AA;  87143 MW;  3A9FD99F03C600AC CRC64;
     MEHHCGLITS NKETVPLKNI SVTLSINEFV AAVVATLNYE NEEKVPLEAT FVFPMDEDSA
     VYSFEALVDG KKIVAELQDK MKAHSEYEEA LSQGHQAYLL EEDDYSRDVF SCNVGNLQPG
     AKVAVTLRYV QELPLETDGA LRYLLPAILN PRYQLSEQSA NSCLNIQKPT VPLEDLPYTL
     NMTATITSQH GIERVQSNCS LSPIQYLTDD KTSAQVSLTE GHKFDRDVEL LIYYNEVHSP
     SVAVEMGMLD MKPDSLMGAP SAMVSFYPDI PEVEASKACG EFVFLMDRSG SMDSPMSTEN
     NSQLRIEAAK ETLLLLLKSL PMGCYFNIYG FGSSYEKFFP ESVKYTQDTM EDAVKRVKAL
     KANLGGTEIL TPLCNIYKAS SIPGHPLQLF VFTDGEVSDT FSVIREVKLN SKKHRCFSFG
     IGQGASTSLI KNIARVSGGT AVFITGKDRM QTKALGSLKF ALQCAVDNIS LSWDLPPGLS
     VKMLSPEQLT IFRGQRLIIY AQLTGLMPQV ESTGAVCLKH ILQGRSLENR VTFSLQPKAN
     DNFTIHRLAA KSLIQTKDFG SQEASKEEKE DVMNISLQSG VLSSFTAFIA INKELNKPVQ
     GPLAHRVIPR PVMAGSSSMR FYSSFSGGFK GPQPRSLRVP AYDLCSAESA NLVLKKSACS
     AIQKKKTNSS TNKSNLKKEH KAFGENAVVQ LISLQKANGS WELDEDLTKI LGTKSKDIKA
     ANPAKHEDPS AWSTVLAVVW LHANGTDLKC EWELLERKAV AWLHDHAGSS IPMLVQAANS
     LLKLSVNPAV FGV
 
 
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