VMAC_HUMAN
ID VMAC_HUMAN Reviewed; 169 AA.
AC Q2NL98; B3KW55;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Vimentin-type intermediate filament-associated coiled-coil protein;
GN Name=VMAC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q2NL98; Q8N9N5-2: BANP; NbExp=4; IntAct=EBI-2803134, EBI-11524452;
CC Q2NL98; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-2803134, EBI-2556193;
CC Q2NL98; P25791-3: LMO2; NbExp=3; IntAct=EBI-2803134, EBI-11959475;
CC Q2NL98; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-2803134, EBI-11742507;
CC Q2NL98; P61968: LMO4; NbExp=3; IntAct=EBI-2803134, EBI-2798728;
CC Q2NL98; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-2803134, EBI-739832;
CC Q2NL98; Q96IV0: NGLY1; NbExp=3; IntAct=EBI-2803134, EBI-6165879;
CC Q2NL98; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-2803134, EBI-12000762;
CC Q2NL98; P25786: PSMA1; NbExp=3; IntAct=EBI-2803134, EBI-359352;
CC Q2NL98; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-2803134, EBI-748391;
CC Q2NL98; Q58EX2: SDK2; NbExp=3; IntAct=EBI-2803134, EBI-2801316;
CC Q2NL98; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-2803134, EBI-742688;
CC Q2NL98; Q01664: TFAP4; NbExp=3; IntAct=EBI-2803134, EBI-2514218;
CC Q2NL98; P24278: ZBTB25; NbExp=3; IntAct=EBI-2803134, EBI-739899;
CC Q2NL98; Q5BKZ1: ZNF326; NbExp=3; IntAct=EBI-2803134, EBI-2560158;
CC Q2NL98; P51504: ZNF80; NbExp=3; IntAct=EBI-2803134, EBI-12013828;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes with
CC vimentin-type intermediate filaments. {ECO:0000250}.
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DR EMBL; AK124162; BAG54017.1; -; mRNA.
DR EMBL; BC110802; AAI10803.1; -; mRNA.
DR CCDS; CCDS32881.1; -.
DR RefSeq; NP_001017921.1; NM_001017921.3.
DR AlphaFoldDB; Q2NL98; -.
DR SMR; Q2NL98; -.
DR BioGRID; 134697; 22.
DR IntAct; Q2NL98; 30.
DR MINT; Q2NL98; -.
DR STRING; 9606.ENSP00000343348; -.
DR iPTMnet; Q2NL98; -.
DR PhosphoSitePlus; Q2NL98; -.
DR BioMuta; VMAC; -.
DR DMDM; 121941615; -.
DR EPD; Q2NL98; -.
DR jPOST; Q2NL98; -.
DR MassIVE; Q2NL98; -.
DR PaxDb; Q2NL98; -.
DR PeptideAtlas; Q2NL98; -.
DR PRIDE; Q2NL98; -.
DR ProteomicsDB; 61425; -.
DR Antibodypedia; 77776; 4 antibodies from 4 providers.
DR DNASU; 400673; -.
DR Ensembl; ENST00000339485.4; ENSP00000343348.2; ENSG00000187650.4.
DR GeneID; 400673; -.
DR KEGG; hsa:400673; -.
DR MANE-Select; ENST00000339485.4; ENSP00000343348.2; NM_001017921.4; NP_001017921.1.
DR UCSC; uc002mds.5; human.
DR CTD; 400673; -.
DR DisGeNET; 400673; -.
DR GeneCards; VMAC; -.
DR HGNC; HGNC:33803; VMAC.
DR HPA; ENSG00000187650; Low tissue specificity.
DR neXtProt; NX_Q2NL98; -.
DR OpenTargets; ENSG00000187650; -.
DR PharmGKB; PA165394584; -.
DR VEuPathDB; HostDB:ENSG00000187650; -.
DR eggNOG; ENOG502SD5N; Eukaryota.
DR GeneTree; ENSGT00390000007212; -.
DR HOGENOM; CLU_136281_0_0_1; -.
DR InParanoid; Q2NL98; -.
DR OMA; KICQRRP; -.
DR OrthoDB; 1518511at2759; -.
DR PhylomeDB; Q2NL98; -.
DR TreeFam; TF332566; -.
DR PathwayCommons; Q2NL98; -.
DR SignaLink; Q2NL98; -.
DR BioGRID-ORCS; 400673; 13 hits in 1074 CRISPR screens.
DR ChiTaRS; VMAC; human.
DR GenomeRNAi; 400673; -.
DR Pharos; Q2NL98; Tdark.
DR PRO; PR:Q2NL98; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q2NL98; protein.
DR Bgee; ENSG00000187650; Expressed in granulocyte and 95 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0045098; C:type III intermediate filament; IBA:GO_Central.
DR InterPro; IPR038809; VMAC.
DR PANTHER; PTHR34707:SF1; PTHR34707:SF1; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Reference proteome.
FT CHAIN 1..169
FT /note="Vimentin-type intermediate filament-associated
FT coiled-coil protein"
FT /id="PRO_0000319066"
FT REGION 126..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 7..89
FT /evidence="ECO:0000255"
FT COMPBIAS 132..146
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 169 AA; 18348 MW; 9A3DF7957BC3D69A CRC64;
MSAPPALQIR EANAHLAAVH RRAAELEARL DAAERTVHAQ AERLALHDQQ LRAALDELGR
AKDREIATLQ EQLMTSEATV HSLQATVHQR DELIRQLQPR AELLQDICRR RPPLAGLLDA
LAEAERLGPL PASDPGHPPP GGPGPPLDNS TGEEADRDHL QPAVFGTTV
