ID   VMAC_MOUSE              Reviewed;         174 AA.
AC   Q8BP01; Q3UKV2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Vimentin-type intermediate filament-associated coiled-coil protein;
GN   Name=Vmac;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD;
RC   TISSUE=Dendritic cell, Muellerian duct, and Placenta;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Pancreas;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes with
CC       vimentin-type intermediate filaments. {ECO:0000250}.
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DR   EMBL; AK078549; BAC37331.1; -; mRNA.
DR   EMBL; AK145854; BAE26699.1; -; mRNA.
DR   EMBL; AK170944; BAE42132.1; -; mRNA.
DR   EMBL; BC026472; AAH26472.1; -; mRNA.
DR   CCDS; CCDS28912.1; -.
DR   RefSeq; NP_849257.1; NM_178926.3.
DR   AlphaFoldDB; Q8BP01; -.
DR   SMR; Q8BP01; -.
DR   BioGRID; 223102; 4.
DR   IntAct; Q8BP01; 1.
DR   iPTMnet; Q8BP01; -.
DR   PhosphoSitePlus; Q8BP01; -.
DR   MaxQB; Q8BP01; -.
DR   PaxDb; Q8BP01; -.
DR   PRIDE; Q8BP01; -.
DR   ProteomicsDB; 299953; -.
DR   Antibodypedia; 77776; 4 antibodies from 4 providers.
DR   DNASU; 106639; -.
DR   Ensembl; ENSMUST00000067931; ENSMUSP00000064120; ENSMUSG00000054723.
DR   GeneID; 106639; -.
DR   KEGG; mmu:106639; -.
DR   UCSC; uc008dcx.2; mouse.
DR   CTD; 400673; -.
DR   MGI; MGI:2146912; Vmac.
DR   VEuPathDB; HostDB:ENSMUSG00000054723; -.
DR   eggNOG; ENOG502SD5N; Eukaryota.
DR   GeneTree; ENSGT00390000007212; -.
DR   HOGENOM; CLU_136281_0_0_1; -.
DR   InParanoid; Q8BP01; -.
DR   OMA; KICQRRP; -.
DR   OrthoDB; 1518511at2759; -.
DR   PhylomeDB; Q8BP01; -.
DR   TreeFam; TF332566; -.
DR   BioGRID-ORCS; 106639; 2 hits in 71 CRISPR screens.
DR   PRO; PR:Q8BP01; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q8BP01; protein.
DR   Bgee; ENSMUSG00000054723; Expressed in lacrimal gland and 147 other tissues.
DR   ExpressionAtlas; Q8BP01; baseline and differential.
DR   Genevisible; Q8BP01; MM.
DR   GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR   GO; GO:0045098; C:type III intermediate filament; ISO:MGI.
DR   InterPro; IPR038809; VMAC.
DR   PANTHER; PTHR34707:SF1; PTHR34707:SF1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..174
FT                   /note="Vimentin-type intermediate filament-associated
FT                   coiled-coil protein"
FT                   /id="PRO_0000319067"
FT   REGION          128..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          7..97
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   174 AA;  19017 MW;  F6FFF022B4E43896 CRC64;
     MSAPPPLQIR EANAHLAAVH RRAAELERRL LAAERTIGAQ AERLACHDQH LRAALDELGR
     AKDREISALQ EQLLSSEATV RSLQAAVDQR DQMIQQLQPR ADLLQDITRH RPPLAALLAT
     LEEAEELGPL PASHSHRAQL LPDGPGPPLG NNMGKEEGQD DQDDQQPAVF GTTV