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VMAT2_HUMAN
ID   VMAT2_HUMAN             Reviewed;         514 AA.
AC   Q05940; B2RC96; D3DRC4; Q15876; Q4G147; Q5VW49; Q9H3P6;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 193.
DE   RecName: Full=Synaptic vesicular amine transporter;
DE   AltName: Full=Monoamine transporter;
DE   AltName: Full=Solute carrier family 18 member 2;
DE   AltName: Full=Vesicular amine transporter 2;
DE            Short=VAT2;
GN   Name=SLC18A2; Synonyms=SVMT, VMAT2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=8095030; DOI=10.1016/0014-5793(93)80539-7;
RA   Surratt C.K., Persico A.M., Yang X.D., Edgar S.R., Bird G.S., Hawkins A.L.,
RA   Griffin C.A., Li X., Jabs E.W., Uhl G.R.;
RT   "A human synaptic vesicle monoamine transporter cDNA predicts
RT   posttranslational modifications, reveals chromosome 10 gene localization
RT   and identifies TaqI RFLPs.";
RL   FEBS Lett. 318:325-330(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=8245983; DOI=10.1111/j.1471-4159.1993.tb07476.x;
RA   Erickson J.D., Eiden L.E.;
RT   "Functional identification and molecular cloning of a human brain vesicle
RT   monoamine transporter.";
RL   J. Neurochem. 61:2314-2317(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Substantia nigra;
RX   PubMed=7905859; DOI=10.1016/s0888-7543(05)80383-0;
RA   Peter D., Finn J.P., Klisak I., Liu Y., Kojis T., Heinzmann C., Roghani A.,
RA   Sparkes R.S., Edwards R.H.;
RT   "Chromosomal localization of the human vesicular amine transporter genes.";
RL   Genomics 18:720-723(1993).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=8373557; DOI=10.1007/bf01244941;
RA   Lesch K.P., Gross J., Wolozin B.L., Murphy D.L., Riederer P.;
RT   "Extensive sequence divergence between the human and rat brain vesicular
RT   monoamine transporter: possible molecular basis for species differences in
RT   the susceptibility to MPP+.";
RL   J. Neural Transm. 93:75-82(1993).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11443533; DOI=10.1038/sj.mp.4000895;
RA   Kunugi H., Ishida S., Akahane A., Nanko S.;
RT   "Exon/intron boundaries, novel polymorphisms, and association analysis with
RT   schizophrenia of the human synaptic vesicle monoamine transporter (SVMT)
RT   gene.";
RL   Mol. Psychiatry 6:456-460(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Uterus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [10]
RP   DISULFIDE BOND.
RX   PubMed=12009896; DOI=10.1021/bi015779j;
RA   Thiriot D.S., Sievert M.K., Ruoho A.E.;
RT   "Identification of human vesicle monoamine transporter (VMAT2) lumenal
RT   cysteines that form an intramolecular disulfide bond.";
RL   Biochemistry 41:6346-6353(2002).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Platelet;
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schuetz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [12]
RP   INVOLVEMENT IN PKDYS2, VARIANT PKDYS2 LEU-387, FUNCTION, AND
RP   CHARACTERIZATION OF VARIANT PKDYS2 LEU-387.
RX   PubMed=23363473; DOI=10.1056/nejmoa1207281;
RA   Rilstone J.J., Alkhater R.A., Minassian B.A.;
RT   "Brain dopamine-serotonin vesicular transport disease and its treatment.";
RL   N. Engl. J. Med. 368:543-550(2013).
CC   -!- FUNCTION: Involved in the ATP-dependent vesicular transport of biogenic
CC       amine neurotransmitters. Pumps cytosolic monoamines including dopamine,
CC       norepinephrine, serotonin, and histamine into synaptic vesicles
CC       (PubMed:23363473). Requisite for vesicular amine storage prior to
CC       secretion via exocytosis. {ECO:0000269|PubMed:23363473}.
CC   -!- SUBUNIT: Interacts with SLC6A3. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q05940; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-18036244, EBI-12244618;
CC       Q05940; Q9BXR6: CFHR5; NbExp=3; IntAct=EBI-18036244, EBI-11579371;
CC       Q05940; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-18036244, EBI-11522780;
CC       Q05940; P25025: CXCR2; NbExp=3; IntAct=EBI-18036244, EBI-2835281;
CC       Q05940; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-18036244, EBI-11955647;
CC       Q05940; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18036244, EBI-3920969;
CC       Q05940; Q16617: NKG7; NbExp=3; IntAct=EBI-18036244, EBI-3919611;
CC       Q05940; P30825: SLC7A1; NbExp=3; IntAct=EBI-18036244, EBI-4289564;
CC       Q05940; Q9BVC6: TMEM109; NbExp=3; IntAct=EBI-18036244, EBI-1057733;
CC       Q05940; Q96B49: TOMM6; NbExp=3; IntAct=EBI-18036244, EBI-10826510;
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Multi-pass membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q05940-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q05940-2; Sequence=VSP_057151, VSP_057152;
CC   -!- DISEASE: Parkinsonism-dystonia 2, infantile-onset (PKDYS2)
CC       [MIM:618049]: An autosomal recessive disorder characterized by
CC       infantile onset of abnormal movements, including parkinsonism,
CC       dystonia, and poor fine motor skills, as well as autonomic dysfunction,
CC       including abnormal sweating, cold extremities, and poor sleep. Some
CC       patients have variable degrees of developmental delay.
CC       {ECO:0000269|PubMed:23363473}. Note=The disease is caused by variants
CC       affecting the gene represented in this entry.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Vesicular
CC       transporter family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB19009.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Vesicular monoamine transporter
CC       entry;
CC       URL="https://en.wikipedia.org/wiki/Vesicular_monoamine_transporter";
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DR   EMBL; L09118; AAA59877.1; -; mRNA.
DR   EMBL; L23205; AAA61290.1; -; mRNA.
DR   EMBL; L14269; AAA91853.1; -; mRNA.
DR   EMBL; X71354; CAA50489.1; -; mRNA.
DR   EMBL; AB044401; BAB19009.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AK314997; BAG37493.1; -; mRNA.
DR   EMBL; AL391988; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL731557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471066; EAW49428.1; -; Genomic_DNA.
DR   EMBL; CH471066; EAW49429.1; -; Genomic_DNA.
DR   EMBL; BC030593; AAH30593.1; -; mRNA.
DR   EMBL; BC108927; AAI08928.1; -; mRNA.
DR   EMBL; BC108928; AAI08929.1; -; mRNA.
DR   CCDS; CCDS7599.1; -. [Q05940-1]
DR   PIR; A49368; A49368.
DR   PIR; S29810; S29810.
DR   RefSeq; NP_003045.2; NM_003054.4. [Q05940-1]
DR   AlphaFoldDB; Q05940; -.
DR   SMR; Q05940; -.
DR   BioGRID; 112459; 104.
DR   IntAct; Q05940; 10.
DR   STRING; 9606.ENSP00000298472; -.
DR   BindingDB; Q05940; -.
DR   ChEMBL; CHEMBL1893; -.
DR   DrugBank; DB01472; 4-Methoxyamphetamine.
DR   DrugBank; DB00182; Amphetamine.
DR   DrugBank; DB00714; Apomorphine.
DR   DrugBank; DB00865; Benzphetamine.
DR   DrugBank; DB01089; Deserpidine.
DR   DrugBank; DB12161; Deutetrabenazine.
DR   DrugBank; DB01576; Dextroamphetamine.
DR   DrugBank; DB00988; Dopamine.
DR   DrugBank; DB01363; Ephedra sinica root.
DR   DrugBank; DB01364; Ephedrine.
DR   DrugBank; DB00502; Haloperidol.
DR   DrugBank; DB05381; Histamine.
DR   DrugBank; DB06706; Isometheptene.
DR   DrugBank; DB00579; Mazindol.
DR   DrugBank; DB01577; Metamfetamine.
DR   DrugBank; DB01454; Midomafetamine.
DR   DrugBank; DB01442; MMDA.
DR   DrugBank; DB04821; Nomifensine.
DR   DrugBank; DB00368; Norepinephrine.
DR   DrugBank; DB06714; Propylhexedrine.
DR   DrugBank; DB09363; Rauwolfia serpentina root.
DR   DrugBank; DB00206; Reserpine.
DR   DrugBank; DB08839; Serotonin.
DR   DrugBank; DB04844; Tetrabenazine.
DR   DrugCentral; Q05940; -.
DR   GuidetoPHARMACOLOGY; 1012; -.
DR   TCDB; 2.A.1.2.29; the major facilitator superfamily (mfs).
DR   GlyGen; Q05940; 2 sites.
DR   iPTMnet; Q05940; -.
DR   PhosphoSitePlus; Q05940; -.
DR   BioMuta; SLC18A2; -.
DR   DMDM; 1722742; -.
DR   EPD; Q05940; -.
DR   jPOST; Q05940; -.
DR   MassIVE; Q05940; -.
DR   PaxDb; Q05940; -.
DR   PeptideAtlas; Q05940; -.
DR   PRIDE; Q05940; -.
DR   ProteomicsDB; 58362; -. [Q05940-1]
DR   ABCD; Q05940; 1 sequenced antibody.
DR   Antibodypedia; 2802; 394 antibodies from 38 providers.
DR   DNASU; 6571; -.
DR   Ensembl; ENST00000644641.2; ENSP00000496339.1; ENSG00000165646.14. [Q05940-1]
DR   GeneID; 6571; -.
DR   KEGG; hsa:6571; -.
DR   MANE-Select; ENST00000644641.2; ENSP00000496339.1; NM_003054.6; NP_003045.2.
DR   UCSC; uc001ldd.3; human. [Q05940-1]
DR   CTD; 6571; -.
DR   DisGeNET; 6571; -.
DR   GeneCards; SLC18A2; -.
DR   HGNC; HGNC:10935; SLC18A2.
DR   HPA; ENSG00000165646; Tissue enhanced (brain, cervix).
DR   MalaCards; SLC18A2; -.
DR   MIM; 193001; gene.
DR   MIM; 618049; phenotype.
DR   neXtProt; NX_Q05940; -.
DR   OpenTargets; ENSG00000165646; -.
DR   Orphanet; 352649; Brain dopamine-serotonin vesicular transport disease.
DR   PharmGKB; PA325; -.
DR   VEuPathDB; HostDB:ENSG00000165646; -.
DR   eggNOG; KOG3764; Eukaryota.
DR   GeneTree; ENSGT00940000157593; -.
DR   HOGENOM; CLU_001265_10_9_1; -.
DR   InParanoid; Q05940; -.
DR   OMA; IVAPLWG; -.
DR   OrthoDB; 956763at2759; -.
DR   PhylomeDB; Q05940; -.
DR   TreeFam; TF313494; -.
DR   PathwayCommons; Q05940; -.
DR   Reactome; R-HSA-181429; Serotonin Neurotransmitter Release Cycle.
DR   Reactome; R-HSA-181430; Norepinephrine Neurotransmitter Release Cycle.
DR   Reactome; R-HSA-212676; Dopamine Neurotransmitter Release Cycle.
DR   Reactome; R-HSA-442660; Na+/Cl- dependent neurotransmitter transporters.
DR   SignaLink; Q05940; -.
DR   SIGNOR; Q05940; -.
DR   BioGRID-ORCS; 6571; 9 hits in 1077 CRISPR screens.
DR   ChiTaRS; SLC18A2; human.
DR   GeneWiki; Vesicular_monoamine_transporter_2; -.
DR   GenomeRNAi; 6571; -.
DR   Pharos; Q05940; Tclin.
DR   PRO; PR:Q05940; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; Q05940; protein.
DR   Bgee; ENSG00000165646; Expressed in substantia nigra pars reticulata and 121 other tissues.
DR   Genevisible; Q05940; HS.
DR   GO; GO:0005813; C:centrosome; IDA:HPA.
DR   GO; GO:0070083; C:clathrin-sculpted monoamine transport vesicle membrane; TAS:Reactome.
DR   GO; GO:0098691; C:dopaminergic synapse; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008021; C:synaptic vesicle; TAS:ParkinsonsUK-UCL.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR   GO; GO:0008504; F:monoamine transmembrane transporter activity; TAS:Reactome.
DR   GO; GO:0005335; F:serotonin:sodium symporter activity; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015842; P:aminergic neurotransmitter loading into synaptic vesicle; IBA:GO_Central.
DR   GO; GO:0007268; P:chemical synaptic transmission; TAS:ParkinsonsUK-UCL.
DR   GO; GO:0015872; P:dopamine transport; TAS:ParkinsonsUK-UCL.
DR   GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR   GO; GO:0015844; P:monoamine transport; TAS:ProtInc.
DR   GO; GO:1903427; P:negative regulation of reactive oxygen species biosynthetic process; NAS:ParkinsonsUK-UCL.
DR   GO; GO:0098700; P:neurotransmitter loading into synaptic vesicle; TAS:ParkinsonsUK-UCL.
DR   GO; GO:0006836; P:neurotransmitter transport; TAS:Reactome.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR   GO; GO:0009636; P:response to toxic substance; IEA:Ensembl.
DR   GO; GO:0042137; P:sequestering of neurotransmitter; NAS:ParkinsonsUK-UCL.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cytoplasmic vesicle; Disease variant; Disulfide bond;
KW   Dystonia; Glycoprotein; Membrane; Neurotransmitter transport; Parkinsonism;
KW   Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..514
FT                   /note="Synaptic vesicular amine transporter"
FT                   /id="PRO_0000127514"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..129
FT                   /note="Lumenal, vesicle"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        151..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..189
FT                   /note="Lumenal, vesicle"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        211..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        243..248
FT                   /note="Lumenal, vesicle"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        272..291
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        312..328
FT                   /note="Lumenal, vesicle"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        353..357
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        379..389
FT                   /note="Lumenal, vesicle"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        411..414
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        436..440
FT                   /note="Lumenal, vesicle"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        441..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        463..514
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         511
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01827"
FT   MOD_RES         513
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q01827"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        117..324
FT                   /evidence="ECO:0000269|PubMed:12009896"
FT   VAR_SEQ         204..209
FT                   /note="MGMLAS -> RCGMPE (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_057151"
FT   VAR_SEQ         210..514
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_057152"
FT   VARIANT         387
FT                   /note="P -> L (in PKDYS2; strong decrease in serotonin
FT                   transport; dbSNP:rs1392638187)"
FT                   /evidence="ECO:0000269|PubMed:23363473"
FT                   /id="VAR_081069"
FT   CONFLICT        17
FT                   /note="R -> H (in Ref. 4; CAA50489)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        302
FT                   /note="C -> S (in Ref. 1; AAA59877)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        354
FT                   /note="K -> T (in Ref. 1; AAA59877)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        378
FT                   /note="A -> P (in Ref. 1; AAA59877)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        395
FT                   /note="I -> N (in Ref. 1; AAA59877)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   514 AA;  55713 MW;  42EA91A225485DB2 CRC64;
     MALSELALVR WLQESRRSRK LILFIVFLAL LLDNMLLTVV VPIIPSYLYS IKHEKNATEI
     QTARPVHTAS ISDSFQSIFS YYDNSTMVTG NATRDLTLHQ TATQHMVTNA SAVPSDCPSE
     DKDLLNENVQ VGLLFASKAT VQLITNPFIG LLTNRIGYPI PIFAGFCIMF VSTIMFAFSS
     SYAFLLIARS LQGIGSSCSS VAGMGMLASV YTDDEERGNV MGIALGGLAM GVLVGPPFGS
     VLYEFVGKTA PFLVLAALVL LDGAIQLFVL QPSRVQPESQ KGTPLTTLLK DPYILIAAGS
     ICFANMGIAM LEPALPIWMM ETMCSRKWQL GVAFLPASIS YLIGTNIFGI LAHKMGRWLC
     ALLGMIIVGV SILCIPFAKN IYGLIAPNFG VGFAIGMVDS SMMPIMGYLV DLRHVSVYGS
     VYAIADVAFC MGYAIGPSAG GAIAKAIGFP WLMTIIGIID ILFAPLCFFL RSPPAKEEKM
     AILMDHNCPI KTKMYTQNNI QSYPIGEDEE SESD
 
 
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