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VME1_BC512
ID   VME1_BC512              Reviewed;         227 AA.
AC   Q0Q463;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Membrane protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE            Short=M protein {ECO:0000255|HAMAP-Rule:MF_04201};
DE   AltName: Full=E1 glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE   AltName: Full=Matrix glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
DE   AltName: Full=Membrane glycoprotein {ECO:0000255|HAMAP-Rule:MF_04201};
GN   Name=M {ECO:0000255|HAMAP-Rule:MF_04201}; ORFNames=5;
OS   Bat coronavirus 512/2005 (BtCoV) (BtCoV/512/2005).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Alphacoronavirus; Pedacovirus.
OX   NCBI_TaxID=693999;
OH   NCBI_TaxID=153297; Scotophilus kuhlii (Lesser asiatic yellow bat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16840328; DOI=10.1128/jvi.00697-06;
RA   Tang X.C., Zhang J.X., Zhang S.Y., Wang P., Fan X.H., Li L.F., Li G.,
RA   Dong B.Q., Liu W., Cheung C.L., Xu K.M., Song W.J., Vijaykrishna D.,
RA   Poon L.L.M., Peiris J.S.M., Smith G.J., Chen H., Guan Y.;
RT   "Prevalence and genetic diversity of coronaviruses in bats from China.";
RL   J. Virol. 80:7481-7490(2006).
CC   -!- FUNCTION: Component of the viral envelope that plays a central role in
CC       virus morphogenesis and assembly via its interactions with other viral
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC       compartment of the host cell, which is located between endoplasmic
CC       reticulum and the Golgi complex. Forms a complex with HE and S
CC       proteins. Interacts with nucleocapsid N protein. This interaction
CC       probably participates in RNA packaging into the virus.
CC       {ECO:0000255|HAMAP-Rule:MF_04201, ECO:0000255|PROSITE-
CC       ProRule:PRU01275}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04201}. Host Golgi apparatus membrane {ECO:0000255|HAMAP-
CC       Rule:MF_04201}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_04201}. Note=Largely embedded in the lipid bilayer.
CC       {ECO:0000255|HAMAP-Rule:MF_04201}.
CC   -!- MISCELLANEOUS: Bat coronavirus 512/2005 is highly similar to porcine
CC       epidemic diarrhea virus (PEDV).
CC   -!- SIMILARITY: Belongs to the alphacoronaviruses M protein family.
CC       {ECO:0000255|HAMAP-Rule:MF_04201}.
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DR   EMBL; DQ648858; ABG47081.1; -; Genomic_RNA.
DR   RefSeq; YP_001351687.1; NC_009657.1.
DR   SMR; Q0Q463; -.
DR   GeneID; 11266521; -.
DR   KEGG; vg:11266521; -.
DR   Proteomes; UP000113079; Genome.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-UniRule.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-UniRule.
DR   CDD; cd21564; alphaCoV_M; 1.
DR   HAMAP; MF_04201; ALPHA_CORONA_M; 1.
DR   InterPro; IPR042551; ALPHA_CORONA_M.
DR   InterPro; IPR002574; M_CoV.
DR   Pfam; PF01635; CoV_M; 1.
DR   PROSITE; PS51927; COV_M; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host Golgi apparatus; Host membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Viral matrix protein; Virion.
FT   CHAIN           1..227
FT                   /note="Membrane protein"
FT                   /id="PRO_0000289935"
FT   TOPO_DOM        1..12
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TRANSMEM        13..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TOPO_DOM        34..42
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TOPO_DOM        64..76
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   TOPO_DOM        98..227
FT                   /note="Intravirion"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
FT   REGION          201..217
FT                   /note="Interaction with N protein"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04201"
SQ   SEQUENCE   227 AA;  25666 MW;  41CFA6EFC2BB303D CRC64;
     MSSNQSVPVE EVIKHLRNWN FSWNIILTIL LVVLQYGHYK YSRVLYGLKM AILWLLWPLV
     LALSIFDAWA SFNVNWVFFA FSILMACVTA VLWIMYFVNS IRLWRRTHSW WSYNPETDSI
     LSVSVLGRHV CLPILGAPTG VTLTLLNGTL LVEGYQVATG VQVNNLPGYV TVAKASTTIV
     YQRVGRSMNA NSSTGWAFFV KSKHGDYYAA ANPTEVVTDS EKILHLV
 
 
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