VME1_BEV
ID VME1_BEV Reviewed; 233 AA.
AC P27904;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Membrane protein;
DE Short=M protein;
DE AltName: Full=E1 glycoprotein;
DE AltName: Full=Matrix glycoprotein;
DE AltName: Full=Membrane glycoprotein;
GN Name=M;
OS Berne virus (BEV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Nidovirales; Tornidovirineae; Tobaniviridae; Torovirinae; Torovirus;
OC Renitovirus; Equine torovirus.
OX NCBI_TaxID=11156;
OH NCBI_TaxID=9796; Equus caballus (Horse).
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Isolate P138/72;
RX PubMed=2024492; DOI=10.1016/0042-6822(91)90606-c;
RA den Boon J.A., Snijder E.J., Locker J.K., Horzinek M.C., Rottier P.J.M.;
RT "Another triple-spanning envelope protein among intracellularly budding RNA
RT viruses: the torovirus E protein.";
RL Virology 182:655-663(1991).
CC -!- FUNCTION: Component of the viral envelope that plays a central role in
CC virus morphogenesis and assembly via its interactions with other viral
CC proteins. {ECO:0000250}.
CC -!- SUBUNIT: Homomultimer. Interacts with envelope E protein in the budding
CC compartment of the host cell, which is located between endoplasmic
CC reticulum and the Golgi complex. Forms a complex with HE and S
CC proteins. Interacts with nucleocapsid N protein. This interaction
CC probably participates in RNA packaging into the virus (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}. Host Golgi apparatus membrane
CC {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Largely
CC embedded in the lipid bilayer. {ECO:0000250}.
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DR EMBL; X52505; CAA36747.1; -; mRNA.
DR PIR; A39989; VMWJBV.
DR Proteomes; UP000006571; Genome.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039660; F:structural constituent of virion; IEA:UniProtKB-KW.
DR InterPro; IPR024251; M_Torovirus.
DR Pfam; PF10943; DUF2632; 1.
PE 2: Evidence at transcript level;
KW Host Golgi apparatus; Host membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Viral envelope protein;
KW Viral matrix protein; Virion.
FT CHAIN 1..233
FT /note="Membrane protein"
FT /id="PRO_0000106129"
FT TOPO_DOM 1..31
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..69
FT /note="Intravirion"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..93
FT /note="Virion surface"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..233
FT /note="Intravirion"
FT /evidence="ECO:0000255"
SQ SEQUENCE 233 AA; 26548 MW; A07A34DC539104BE CRC64;
MFETNYWPFP DQAPNPFTAQ IEQLTATENV YIFLTTLFGI LQLVYVMFKL LCTMFPSLHF
SPIWRGLENF WLFLSLASLA IAYWWLPSMT FTGYWALTII ATILVFILLI MMFVKFVNFV
KLFYRTGSFA IAIRGPIVLV ALDVTIKLHC TPFAILVKEI GNIFYLSEYC NKPLTAAQIA
ALRICVNGQW FAYTRSSTTS AARVAAANST AKYHLFVLQG VAEYTQLSSV KFE